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Table 6 Associations between infection by different M. tuberculosis sublineages (according to the SpolDB4[23]) and clinical manifestations

From: Increased level of acute phase reactants in patients infected with modern Mycobacterium tuberculosis genotypes in Mwanza, Tanzania

Groups Reference group: EAI5 (n = 33)
CAS_KILI (n = 44) LAM11_ZWE (n = 51)
Variables Regression coefficient 95% CI P-value Regression coefficient 95% CI P-value
Age (years)1 1.8 [-4.55 – 8.06] 0.58 -0.6 [-6.84 – 5.68] 0.86
Weight (kg/m2)2 -1.0 [-4.37 – 2.48] 0.59 -3.0 [-6.39 – 0.40] 0.08
BMI (kg/m2)2 -0.5 [-1.62 – 0.67] 0.41 -0.9 [-2.07 – 0.19] 0.10
CRP (mg/L)2 13.2 [-11.26 – 37.66] 0.29 24.4 [0.24 – 48.63] 0.05
AGP (g/L)1* 0.2 [-0.15 – 0.62] 0.23 0.4 [-0.01 – 0,73] 0.06
Neutrophil count (x 109 cells/L)2 -0.1 [-0.93 – 0.69] 0.77 0.9 [0.09 – 1.70] 0.03
Lymphocyte count(x 109 cells/L)2 0.4 [-0.02 – 0.91] 0.06 0.3 [-0.18 – 0.74] 0.23
CD4 count (cells/ul)2 38.8 [-91.88 – 169.46] 0.56 -13.0 [-142.54 – 116.53] 0.84
Hemoglobin (g/dl)2 0.1 [-0.90 – 1.12] 0.83 -0.4 [-1.40 – 0.60] 0.43
Fasting blood glucose (mmol/L)2 -0.1 [-0.52 – 0.30] 0.60 -0.3 [-0.68 – 0.14] 0.19
Diabetes2 1.3 [0.35 – 4.99] 0.68 1.1 [0.28 – 4.22] 0.89
Smoking2 1.4 [0.44 – 4.22] 0.60 1.3 [0.41 – 4.19] 0.64
TB contact2 1.1 [0.39 – 3.12] 0.85 1.3 [0.46 – 3.44] 0.66
BCG scar2 1.2 [0.40 – 3.51] 0.76 1.5 [0.51 – 4.60] 0.44
  1. Results are based on a linear and logistic regression models adjusted for age, sex and HIV status.
  2. 1Adjusted for HIV status and gender.
  3. 2Adjusted for HIV status, age and gender.
  4. 3 P-values <0.05 are in bold.
  5. *HIV negative only.
  6. Odds ratio.
  7. BMI: Body Mass Index.
  8. EAI: East-African Indian.
  9. CRP: C-reactive protein.
  10. AGP: Orosomucoid.
  11. BCG: Bacillus Calmette-Guerrin.