Patient characteristics | Patients who developed rCDI | Patients who did not develop rCDI | Hazard ratio |
---|---|---|---|
(n = 425) | (n = 3775) | 95% CI | |
Demographics | |||
Age, years (median[range]) | 64.8 (18.3 – 98.2) | 61.6 (18.0 –102.4) | 1.01 (1.01 – 1.02) |
Gender: female | 210 (49) | 1824 (48) | 1.05 (0.87 – 1.27) |
Comorbiditiesa | |||
Myocardial infarction | 40 (9) | 328 (9) | 1.12 (0.81 – 1.55) |
Congestive heart failure | 108 (25) | 854 (23) | 1.23 (0.99 – 1.53) |
Peripheral vascular disease | 34 (8) | 269 (7) | 1.13 (0.79 – 1.60) |
Cerebrovascular disease | 41 (10) | 256 (7) | 1.51 (1.10 – 2.09) |
Chronic renal failure | 21 (5) | 190 (5) | 0.98 (0.64 – 1.53) |
Dementia | 5 (1) | 23 (1) | 1.83 (0.76 – 4.41) |
Chronic obstructive pulmonary disease | 116 (27) | 912 (24) | 1.18 (0.95 – 1.46) |
Rheumatologic disease | 18 (4) | 146 (4) | 1.11 (0.69 – 1.78) |
Peptic ulcer disease | 20 (5) | 154 (4) | 1.18 (0.75 – 1.85) |
Mild liver disease | 17 (4) | 201 (5) | 0.81 (0.50 – 1.32) |
Moderate to severe liver disease | 12 (3) | 134 (4) | 0.86 (0.48 – 1.53) |
Diabetes | 135 (32) | 975 (26) | 1.32 (1.08 – 1.62) |
Paraplegia or hemiplegia | 12 (3) | 78 (2) | 1.40 (0.79 – 2.45) |
Any malignancy (excluding leukemia/lymphoma) | 83 (20) | 770 (20) | 0.99 (0.78 – 1.25) |
Leukemia or lymphoma | 78 (18) | 660 (18) | 1.05 (0.82 – 1.34) |
Metastatic solid tumor | 56 (13) | 449 (12) | 1.19 (0.90 – 1.58) |
HIV/AIDS | 10 (2) | 66 (2) | 1.30 (0.70 – 2.44) |
Charlson composite score | |||
0-2 | 223 (53) | 2182 (58) | Ref |
3-5 | 117 (28) | 922 (24) | 1.27 (1.01 – 1.59) |
> = 6 | 85(20) | 671 (18) | 1.32 (1.03 – 1.69) |
Case statusb | |||
HCFO/HCFA | 203 (48) | 2332 (62) | Ref |
CA or unknown | 57 (13) | 597 (16) | 1.07 (0.79 – 1.43) |
CO/HCFA, indeterminate, or non- BJH HCFA | 165 (39) | 846 (22) | 2.17 (1.76 – 2.66) |
Admitted from another healthcare facility | 109 (26) | 1019 (27) | 0.97 (0.78 – 1.21) |
Number of inpatient admissions in previous 60 days | |||
0 | 200 (47) | 2313 (61) | Ref |
1 | 150 (35) | 1021 (27) | 1.70 (1.37 – 2.10) |
2+ | 75 (18) | 441 (12) | 1.96 (1.50 – 2.55) |
Baseline laboratory datac | |||
Low albumin at admission | 52 (12) | 522 (14) | 0.94 (0.70 – 1.25) |
Low WBC at admission | 44 (10) | 420 (11) | 0.92 (0.68 – 1.26) |
High WBC at admission | 236 (56) | 2122 (56) | 0.86 (0.66 – 1.12) |
Low hemoglobin at admission | 182 (43) | 1572 (42) | 1.09 (0.90 – 1.32) |
High creatinine at admission | 108 (25) | 947 (25) | 1.04 (0.84 – 1.30) |
Low creatinine clearance | 218 (51) | 1636 (43) | 1.43 (1.18 – 1.73) |