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Table 1 Validation of previously identified Chagas biomarkers within HUG study samples

From: Serum biomarkers predictive of cure in Chagas disease patients after nifurtimox treatment

m/z(/1,000)

Fractions and chemistries

P value (CD + vs HC) AUC for ROC curve (fold CD/HC)

P value (FU vs HC) AUC for ROC curve (fold FU/HC)

P value (CD + vs FU) AUC for ROC curve (fold CD/FU)

Mean signal intensity ± SEM

HC

CD+

FU

(n = 37)

(n = 37)

(n = 37)

3.7

F1 CM10

0.0001, 1.0 (+4.2)

0.0001, 0.88 (+2.3)

0.0011, 0.82 (+1.8)

1.54 ± 0.11

6.46 ± 0.64

3.60 ± 0.45

4.4

F1 IMAC; F1,5 CM10

0.0001, 1.0 (+3.7)

0.0159, 0.69 (+1.7)

0.0001, 0.91 (+2.2)

7.66 ± 0.53

28.35 ± 1.74

12.84 ± 1.91

5.4a

F1, 3 CM10

0.0001, 1.0 (-0.3)

0.0001, 0.99 (-0.2)

0.2427, 0.65 (+1.2)

3.51 ± 0.31

0.90 ± 0.07

0.75 ± 0.10

6.6

F3,5 CM10

0.0001, 1.0 (+3.4)

0.0001, 0.91 (+2.5)

0.0028, 0.79 (+1.4)

3.65 ± 0.26

12.45 ± 0.62

8.96 ± 0.89

7.8

F1,3 CM10

0.0001, 0.97 (+3.9)

0.3405, 0.55 (+1.2)

0.0005, 0.91 (+3.15)

0.55 ± 0.07

2.14 ± 0.35

0.68 ± 0.12

9.3

F1,4 IMAC; F1,3 CM10

0.0001, 0.92 (+1.7)

0.9456, 0.51 (+1.0)

0.0001, 0.87 (+1.7)

2.74 ± 0.26

4.76 ± 0.24

2.77 ± 0.31

10.1

F1,3,4,6 IMAC; F1 CM10

0.0001, 0.88 (+2.0)

0.3622, 0.56 (-0.9)

0.0001, 0.96 (+2.3)

15.27 ± 1.80

30.48 ± 2.92

13.13 ± 1.42

12.7

F2,5 IMAC; F1,5,6 CM10

0.0003, 0.80 (+2.0)

0.5879, 0.53 (+1.2)

0.0129, 0.73 (+1.7)

2.59 ± 0.41

5.27 ± 0.55

3.02 ± 0.68

13.6

F1 IMAC; F1 CM10

0.0001, 0.96 (+2.3)

0.2220, 0.59 (+1.2)

0.0001, 0.86 (+1.8)

4.43 ± 0.51

10.07 ± 0.62

5.50 ± 0.71

15.2

F4,5 IMAC; F1,3,6 CM10

0.0001, 1.0 (+2.9)

0.6538, 0.51 (+1.1)

0.0001, 0.96 (+2.7)

5.62 ± 0.51

16.46 ± 1.33

6.04 ± 0.75

16.3

F4 IMAC; F3,6 CM10

0.0001, 0.95 (+3.1)

0.4349, 0.58 (+1.2)

0.0001, 0.94 (+2.6)

1.77 ± 0.30

5.48 ± 0.48

2.10 ± 0.28

24.7

F2 IMAC

0.0001, 0.84 (+1.8)

0.6429, 0.51 (-0.9)

0.0001, 0.85 (+1.9)

1.48 ± 0.16

2.61 ± 0.19

1.37 ± 0.18

28.1a

F1,3 CM10

0.0001, 0.96 (-0.8)

0.3598, 0.56 (-1.0)

0.0032, 0.79 (-0.8)

28.43 ± 0.63

21.66 ± 1.07

27.06 ± 1.23

28.9

F1 IMAC

0.0001, 0.98 (+3.5)

0.0182, 0.66 (+1.9)

0.0006, 0.80 (+1.9)

0.46 ± 0.07

1.61 ± 0.13

0.86 ± 0.15

75.4

F1 CM10

0.0001, 1.0 (+3.0)

0.0005, 0.83 (+1.9)

0.0001, 0.96 (+1.6)

1.18 ± 0.15

3.53 ± 0.09

2.25 ± 0.23

  1. a Downregulated protein in CD-positive subjects.
  2. Mass (m/z), mean intensities, and AUC’s for selected differentially expressed peptides/proteins between HC, 2008-CD + and 2011-FU sera samples.
  3. An area under the curve (AUC) of 1 suggests good diagnostic power, while AUC values that approach 0.5 indicate little diagnostic potential. HC: Healthy control; CD: Chagas disease; FU: follow-up.
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BMC Infectious Diseases

ISSN: 1471-2334

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