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Table 1 Model parameters, with baseline values imported from[23, 24]

From: A model-based analysis: what potential could there be for a S. aureus vaccine in a hospital setting on top of other preventative measures?

Parameter

Symbol

Baseline value

Total no. of patients

N

400

Fraction of patients colonized with CA-MRSA upon admission

λ CC baseline

0.03

Fraction of patients colonized with HA-MRSA upon admission

λ CH baseline

0.07

Fraction of patients infected with CA-MRSA upon admission

λ IC baseline

0.005

Fraction of patients infected with HA-MRSA upon admission

λ IH baseline

0.0017

Average length of stay susceptible patients

1/γ S

5 days

Average length of stay patients colonized with CA-MRSA

1/γ CC

5 days

Average length of stay patients colonized with HA-MRSA

1/γ CH

7 days

Average length of stay patients infected with CA-MRSA

1/γ IC

10 days

Average length of stay patients infected with HA-MRSA

1/γ IH

18 days

CA-MRSA colonized-to-susceptible patient effective transmission rate

β CC baseline

0.36 day-1

HA-MRSA colonized-to-susceptible patient effective transmission rate

β CH baseline

0.27 day-1

CA-MRSA infected-to-susceptible patient effective transmission rate

β IC baseline

0.09 day-1

HA-MRSA infected-to-susceptible patient effective transmission rate

β IH baseline

0.07 day-1

Infection rate in CA-MRSA colonized patients

φC

0.1 γCC

(10% per day of hospital stay)

Infection rate in HA-MRSA colonized patients

φH

0.1 γCH

(10% per day of hospital stay)

Death rate of CA-MRSA infected patients

δC

0.033 γIC

(3.3% per day of hospital stay)

Death rate of HA-MRSA infected patients

δH

0.2 γIH

(20% per day of hospital stay)

Cure rate of CA-MRSA infected patients

Ï„C

0.967 γIC

(96.7% per day of hospital stay)

Cure rate of HA-MRSA infected patients

Ï„H

0.8 γIH

  

(80% per day of hospital stay)