Association between adherence to an antimicrobial stewardship program and mortality among hospitalised cancer patients with febrile neutropaenia: a prospective cohort study

Table 6 Prognostic factors of 28-day mortality in FN patients by Cox regression multivariate analysis adjusted using a propensity score

Variable	HR (95% CI)	P-value
Relapsing underlying disease status	4.43 (1.65–11.86)	0.003
Documented BSI	3.78 (1.55–9.20)	0.003
High-risk MASCC score	3.01 (1.33–6.83)	0.008
Time to antibiotic >1 h	3.85 (1.71–8.62)	0.001
ASP adherence	0.36 (0.14–0.92)	0.03

Note: Variables entered into the model: propensity score, ASP adherence, time to antibiotic >1 h, in vitro sensitivity of blood isolates to initial antibiotic treatment administered, high-risk MASCC score, documented BSI, BSI involving Gram-negative MDR bacteria, relapsing underlying disease status, hypotension at the time of diagnosis of FN, and high-dose chemotherapy regimens.

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