Table 2 Characteristics of included reviews
From: Interventions to improve delivery of isoniazid preventive therapy: an overview of systematic reviews
Author, year, reference | Systematic review objective(s) | Study settings (no. of studies related to IPT delivery) | Participants | Countries where studies conducted | Percent studies in high TB incidence settinga | Outcome related to TCR | Applicability |
|---|---|---|---|---|---|---|---|
Al-Darraji, 2012 [23] | Review interventions to improve IPT delivery in correctional facilities | Jails and prisons (18) | Adults | US, Spain, Singapore | 6% | Median TCR 44% (3-87%); low TCRs among RCTs (23, 12 and 12%) | Behavior of incarcerated adults may not be generalizable; incomplete HIV prevalence data |
DeFulio, 2012 [24] | Review use of incentives on medication adherence | Methadone, primary care, and public clinics, homeless shelters (5) | Adults and children | US, Timor-Leste | 20% | TCR improved in 2 of 3 studies (44% v. 26% and 92% v. 82%); 1 showed no effect | Behavior of addicted and homeless populations may not be generalizable; only 1 study included children, none specified inclusion of HIV populations |
Hirsch-Moverman, 2008 [26] | To identify predictors of adherence and adherence interventions | Jails, refugee camp, homeless shelter, healthcare setting (19) | IV drug users, incarcerated, homeless, refugee/ foreign-born, healthcare workers, aboriginal populations | US and Canada | 0% | Inconsistent across studies; no single intervention reliably showed effectiveness | Mixed adult populations; lack of regional diversity; incomplete HIV prevalence data |
Lewin, 2010 [9] | To assess the effects of lay health worker interventions in primary and community health care on maternal and child health and the management of infectious diseases | US (2) | IV drug users, adolescents (ages 11-19, mostly Hispanic American) | US | 0% | Little to no effect on treatment completion (RR = 1 · 0) | No children under age 5 included, 20% HIV-infected in one study, HIV status unknown in other study |
Uyei, 2011 [25] | To examine the effect of strategies for TB and HIV service integration on delivery, outcomes for patients, and cost-effectiveness | Counseling and testing centers, hospitals, clinics (6) | HIV-infected patients | Botswana, South Africa, Uganda | 100% | High adherence (75-92%); moderate to high TCRs (47-88%) | Unclear if children included |
Zuñiga, 2012 [27] | To synthesize data on LTBI treatment adherence in Hispanic populations in the US | Clinics and public health programs dispensing LTBI treatment (12) | Hispanic adults | US | 0% | Self-reports of LTBI adherence may be inaccurate; power dynamic impedes patient and healthcare provider communication; direct measures of adherence will improve validity of results | No children included; adult Hispanic populations only, no HIV data |