The second generation of HIV-1 vertically exposed infants: a case series from the Italian Register for paediatric HIV infection

Calitri, Carmelina; Gabiano, Clara; Galli, Luisa; Chiappini, Elena; Giaquinto, Carlo; Buffolano, Wilma; Genovese, Orazio; Esposito, Susanna; Bernardi, Stefania; De Martino, Maurizio; Tovo, Pier-Angelo

doi:10.1186/1471-2334-14-277

Table 2 Pregnancy features

From: The second generation of HIV-1 vertically exposed infants: a case series from the Italian Register for paediatric HIV infection

N.	Birth order	ART therapy at conception	ART therapy interruption at first trimester	ART regimen during pregnancy	Gestational week at start	Gestational week at end	CD4+ at delivery	VL at delivery	AZT intrapartum	Type of delivery
Case 1	1^st	No	No	AZT + 3TC + ATV/rtv	5	37	525	Undetectable	Yes	EC
Case 2	1^st	Yes	Yes (from 5^th to 12^th week)	DDI + 3TC + NVP	1	4	480	157	Yes	EC
				AZT + 3TC + NVP	13	38
	2^nd	Yes	No	FTC + TDF + FPV/rtv	1	38	520	Undetectable	Yes	EC
Case 3	1^st	Yes	No	FTC + TDF + ATV/rtv	1	38	125	Undetectable	Yes	EC
Case 4	1^st	No	No	No			Unknown	Unknown	Yes	EC
Case 5	1^st	No	No	AZT + 3TC + LPV/rtv	23	34	307	Unknown	Yes	EC
	2^nd	Yes	No	AZT + 3TC + LPV/rtv	1	37	480	15332	Yes	EC
	3^th	Yes	No	AZT + 3TC + LPV/rtv	1	Unknown	Unknown	Unknown	Yes	EC
Case 6	1^st	No	No	AZT + 3TC + NVP	6	36	Unknown	Unknown	No	EC
	2^nd	No	No	AZT + 3TC + NVP	6	40	Unknown	Unknown	No	EC
Case 7	1^st	Yes	No	ABC + 3TC + ATV	1	34	323	Undetectable	Yes	EC
				ABC + 3TC + ATV/rtv	35	38
Case 8	1^st	Yes	No	FTC + TDF + DRV/rtv	1	38	450	Undetectable	Yes	EC
Case 9	1^st	Yes	No	ABC + DDI + LPV/rtv	1	16	312	7653	Yes	EC
				AZT + 3TC + LPV/rtv	17	36
Case 10	1^st	Yes	Yes (from 6^th to 12^th week)	FTC + TDF + EFV	1	5	240	Undetectable	Yes	EC
				AZT + 3TC + LPV/rtv	13	38
Case 11	1^st	Unknown	No	ABC + TDF + LPV/rtv	Unknown	39	Unknown	Undetectable	Yes	EC
Case 12	1^st	No	No	No			Unknown	Unknown	Yes	UC
	2^nd	Yes	No	AZT + 3TC + LPV/rtv	1	38	95	Unknown	Yes	EC
Case 13	1^st	Yes	No	FTC + NVP	1	39	673	Undetectable	Yes	EC
Case 14	1^st	Yes	No	AZT + 3TC + ABC	1	35	564	Undetectable	Yes	EC
Case 15	1^st	Yes	No	FTC + TDF + DRV/rtv	1	37	501	Undetectable	Yes	EC
Case 16	1^st	No	No	FTC + TDF + ATV/rtv	16	36	522	Undetectable	Yes	EC
Case 17	1^st	No	No	FTC + TDF + ATV	13	37	770	Undetectable	Yes	EC
Case 18	1^st	Yes	No	3TC	1	28	440	13099	Yes	LC
				FTC + TDF + DRV/rtv	29	36
Case 19	1^st	No	No	FTC + TDF + ATV/rtv	6	38	501	Undetectable	Yes	EC
Case 20	1^st	No	No	FTC + TDF + DRV/rtv + RAL	38	40	200	Undetectable	Yes	EC
	2^nd	Unknown	Unknown	Unknown			99	Unknown	Unknown	Unknown
Case 21	1^st	Yes	No	FTC + TDF + ATV/rtv	1	38	776	615	Yes	EC
Case 22	1^st	Yes	No	AZT + DDI + LPV/rtv	1	35	435	Undetectable	Yes	EC
Case 23	1^st	Yes	Yes (from 3^rd to 9^th week)	FTC + TDF + LPV/rtv	1	3	275	20000	Yes	EC
				FTC + TDF + LPV/rtv	10	38

Legend. VL: viral load (copies/ml); AZT: zidovudine; 3TC: lamivudine; ABC: abacavir; FTC: emtricitabine; TDF: tenofovir; DDI: didanosine; NVP: nevirapine; LPV: lopinavir; ATV: atazanavir; FPV: fosamprenavir; DRV: darunavir; rtv: ritonavir booster; RAL: raltegravir; EC = elective caesarean section; UC = unspecified caesarean section; LC = caesarean section after labour.

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ISSN: 1471-2334

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