Table 1 Demographic and clinical characteristics of patients with sepsis and bloodstream infections of the two study periods
2006-2009 | 2010-2013 | p | |
|---|---|---|---|
Admission in the emergencies and general ward hospitalization | |||
Male gender (n,%) | 120 (49.8) | 121 (42.6) | 0.114 |
Age (years, mean ± SD) | 70.2 ± 16.6 | 73.3 ± 15.3 | 0.034 |
APACHE II (mean ± SD) | 14.33 ± 8.57 | 17.87 ± 8.27 | <0.0001 |
White blood cell count (/mm3, mean ± SD) | 15801.5 ± 11733.0 | 16680.9 ± 10705.6 | 0.371 |
Sepsis severity (n,%) | |||
Uncomplicated sepsis | 152 (62.3) | 151 (52.2) | 0.022 |
Severe sepsis/shock | 92 (37.7) | 138 (47.8) | |
Underlying type of infection (n,%) | |||
Acute pyelonephritis | 119 (48.8) | 148 (51.2) | |
Community-acquired pneumonia | 19 (7.8) | 22 (7.7) | |
Intrabdominal infections | 32 (13.1) | 38 (13.1) | 0.052 |
Primary bacteremia | 69 (28.3) | 71 (24.6) | |
Soft-tissue infections | 3 (1.2) | 4 (1.4) | |
Catheter-related bacteremia | 2 (0.8) | 6 (2.1) | |
Underlying diseases (n,%) | |||
Type 2 diabetes mellitus | 61 (25.0) | 118 (40.8) | <0.0001 |
Chronic heart failure | 42 (17.2) | 70 (24.2) | 0.055 |
COPD | 13 (5.3) | 27 (9.3) | 0.099 |
Chronic renal disease | 15 (6.1) | 32 (11.1) | 0.048 |
Systemic oral corticosteroids | 7 (2.9) | 15 (5.2) | 0.197 |
Solid tumor malignancy | 49 (20.1) | 46 (15.9) | 0.214 |
Predisposing conditions (n,%) | |||
Ischemic stroke | 33 (13.5) | 61 (21.1) | 0.023 |
Dementia | 26 (10.7) | 20 (6.9) | 0.163 |
Gallstones | 29 (11.9) | 22 (7.6) | 0.105 |
Renal stones | 36 (14.8) | 49 (17.0) | 0.553 |
Appropriateness of administered antibiotics (n,%) | 227 (93.0) | 233 (91.4) | 0.364 |
Mortality (n,%) | 45 (18.4) | 95 (32.9) | <0.0001 |
Sepsis developing after ICU admission | |||
Male gender (n,%) | 83 (66.9) | 51 (61.4) | 0.459 |
Age (years, mean ± SD) | 63.6 ± 15.9 | 61.9 ± 19.67 | 0.489 |
APACHE II (mean ± SD) | 21.57 ± 7.15 | 20.99 ± 8.16 | 0.589 |
White blood cell count (/mm3, mean ± SD) | 14747.3 ± 10326.3 | 13193.4 ± 11167.0 | 0.293 |
Sepsis severity (n,%) | |||
Uncomplicated sepsis | 33 (24.6) | 19 (21.8) | 0.634 |
Severe sepsis/shock | 101 (25.4) | 58 (78.2) | |
Underlying type of infection (n,%) | |||
Ventilator-associated pneumonia | 36 (26.9) | 29 (33.3) | |
Intrabdominal infections | 1 (0.7) | 3 (3.4) | 0.034 |
Primary bacteremia | 90 (67.2) | 50 (57.5) | |
Catheter-related bacteremia | 7 (5.2) | 5 (5.7) | |
Underlying diseases (n,%) | |||
Type 2 diabetes mellitus | 38 (28.4) | 20 (30.0) | 0.435 |
Chronic heart failure | 40 (29.9) | 21 (24.1) | 0.441 |
COPD | 41 (30.6) | 17 (19.5) | 0.085 |
Chronic renal disease | 14 (10.4) | 9 (10.3) | 1.000 |
Systemic oral corticosteroids | 9 (6.7) | 13 (14.9) | 0.064 |
Solid tumor malignancy | 14 (10.4) | 6 (6.9) | 0.474 |
Predisposing condition (n,%) | |||
Ischemic stroke | 30 (22.4) | 17 (24.6) | 0.728 |
Multiple injuries | 10 (7.5) | 10 (14.5) | 0.137 |
Appropriateness of administered antimicrobials (n,%) | 104 (77.6) | 62 (71.7) | 0.538 |
Mortality (n,%) | 50 (37.3) | 40 (45.9) | 0.208 |