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Table 4 Cost effectiveness (cost per life years saved) of vaccination strategies for moderate pandemics (R = 1.9 and CFR = 0.25%) and severe pandemics (R = 2.7 and CFR = 1.5%)

From: A model-based economic analysis of pre-pandemic influenza vaccination cost-effectiveness

  Moderate pandemics (R = 1.9 and CFR = 0.25%)
Scenarios SD and AV intervention Cost ($) per LYS
Pre-emptive vaccination Reactive vaccination
Scenario 1: no pandemic occurs none - -
  Pre-emptive + Reactive vaccination Reactive vaccination
Scenario 2: pandemic with virus which does not match pre-emptive vaccine i.e. vaccine efficacy of 0% none $1,627,500 $1,020,000
8 weeks SD + AV $29,684 $20,079
Sustained SD + AV $24,846 $19,074
  Pre-emptive vaccination Reactive vaccination
Scenario 3: pandemic with virus which matches pre-emptive vaccine with efficacy of 30% none $13,622 $1,020,000
8 weeks SD + AV $12,096 $20,079
Sustained SD + AV $15,897 $19,074
  Pre-emptive
vaccination
Reactive vaccination
Scenario 4: pandemic with virus which matches pre-emptive vaccine with efficacy of 75% none $8,013 $1,020,000
8 weeks SD + AV $10,435 $20,079
Sustained SD + AV $13,658 $19,074
  Extreme pandemics (R = 2.7 and CFR = 1.5%)
Scenarios SD and AV intervention Cost ($) per LYS
Pre-emptive vaccination Reactive vaccination
Scenario 1: no pandemic occurs none - -
  Pre-emptive + Reactive vaccination Reactive vaccination
Scenario 2: pandemic with virus which does not match pre-emptive vaccine i.e. vaccine efficacy of 0% none $1,942,222 $1,672,222
8 weeks SD + AV $12,305 $10,312
Sustained SD + AV $4,938 $4,044
  Pre-emptive vaccination Reactive vaccination
Scenario 3: pandemic with virus which matches pre-emptive vaccine with efficacy of 30% none $6,066 $1,672,222
8 weeks SD + AV $3,097 $10,312
Sustained SD + AV $2,811 $4,044
  Pre-emptive vaccination Reactive vaccination
Scenario 4: pandemic with virus which matches pre-emptive vaccine with efficacy of 75% one $1,075 $1,672,222
8 weeks SD + AV $1,454 $10,312
Sustained SD + AV $1,986 $4,044