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Table 3 Crude and adjusted hazard ratio (HR) of treatment interruption by Any Cause (Cox regression)

From: Single tablet regimens are associated with reduced Efavirenz withdrawal in antiretroviral therapy naïve or switching for simplification HIV-infected patients

  HR 95%CI P aHR 95%CI p
Calendar year, per 1 year increase 0.95 0.91-0.99 0.021 1.05 0.97-1.14 0.22
Age, per 1 year increase 0.99 0.97-1.00 0.11 1.00 0.98-1-01 0.61
Male gender 0.67 0.49-0.93 0.015 0.68 0.50-0.95 0.022
Non-Italian nationality 1.30 0.92-1.85 0.13 1.44 0.98-2.11 0.06
IDU (as risk factor) 1.78 1.19-2.66 0.005 1.98 1.27-3.09 0.003
CDC class C 0.90 0.62-1.32 0.60 1.02 0.67-1.55 0.92
Years from HIV diagnosis (per 1 year increase) 1.00 0.97-1.03 0.94 1.00 0.97-1.03 0.98
Naive (vs. switched) 1.49 1.09-2.04 0.013 1.31 0.74-2.32 0.36
Number of treatment lines at EFV start, per 1 year increase 0.92 0.78-1.07 0.26 1.19 0.95-1.47 0.13
Baseline Viral Load, per 1 log increase 1.11 0.95-1.29 0.31 1.06 0.92-1.23 0.43
Nadir CD4, per 50 cells/μL increase 1.04 0.99-1.10 0.06 1.13 1.04-1.24 0.005
Baseline CD4, per 50 cells/μL increase 0.97 0.93-1.01 0.09 0.95 0.89-1.01 0.12
Backbone:       
  TDF + FTC/3TC Ref    Ref   
  ABC + 3TC 0.76 0.28-2.08 0.59 0.61 0.22-1.70 0.34
  AZT + 3TC 1.53 1.07-2.20 0.021 1.50 0.91-2.47 0.11
  Other 1.65 1.10-2.47 0.015 1.69 0.95-3.02 0.08
STR 0.43 0.25-0.75 0.003 0.43 0.23-0.83 0.012
  1. Abbreviations: HR hazard ratio, CI confidence intervals, IDU injecting drug users, TDF tenofovir, FTC emtricitabine, 3TC lamivudine, ABC abacavir, AZT zidovudine, STR single tablet regimen.