Single tablet regimens are associated with reduced Efavirenz withdrawal in antiretroviral therapy naïve or switching for simplification HIV-infected patients

Table 3 Crude and adjusted hazard ratio (HR) of treatment interruption by Any Cause (Cox regression)

	HR	95%CI	P	aHR	95%CI	p
Calendar year, per 1 year increase	0.95	0.91-0.99	0.021	1.05	0.97-1.14	0.22
Age, per 1 year increase	0.99	0.97-1.00	0.11	1.00	0.98-1-01	0.61
Male gender	0.67	0.49-0.93	0.015	0.68	0.50-0.95	0.022
Non-Italian nationality	1.30	0.92-1.85	0.13	1.44	0.98-2.11	0.06
IDU (as risk factor)	1.78	1.19-2.66	0.005	1.98	1.27-3.09	0.003
CDC class C	0.90	0.62-1.32	0.60	1.02	0.67-1.55	0.92
Years from HIV diagnosis (per 1 year increase)	1.00	0.97-1.03	0.94	1.00	0.97-1.03	0.98
Naive (vs. switched)	1.49	1.09-2.04	0.013	1.31	0.74-2.32	0.36
Number of treatment lines at EFV start, per 1 year increase	0.92	0.78-1.07	0.26	1.19	0.95-1.47	0.13
Baseline Viral Load, per 1 log increase	1.11	0.95-1.29	0.31	1.06	0.92-1.23	0.43
Nadir CD4, per 50 cells/μL increase	1.04	0.99-1.10	0.06	1.13	1.04-1.24	0.005
Baseline CD4, per 50 cells/μL increase	0.97	0.93-1.01	0.09	0.95	0.89-1.01	0.12
Backbone:
TDF + FTC/3TC	Ref			Ref
ABC + 3TC	0.76	0.28-2.08	0.59	0.61	0.22-1.70	0.34
AZT + 3TC	1.53	1.07-2.20	0.021	1.50	0.91-2.47	0.11
Other	1.65	1.10-2.47	0.015	1.69	0.95-3.02	0.08
STR	0.43	0.25-0.75	0.003	0.43	0.23-0.83	0.012

Abbreviations: HR hazard ratio, CI confidence intervals, IDU injecting drug users, TDF tenofovir, FTC emtricitabine, 3TC lamivudine, ABC abacavir, AZT zidovudine, STR single tablet regimen.

ISSN: 1471-2334