Combination of gene expression patterns in whole blood discriminate between tuberculosis infection states

BMC Infectious Diseases

Table 2 General discriminate analysis of five marker combinations to discriminate active TB and household contacts

	Household contacts		TB cases
	Resubstitution classification	Leave-one-out cross	Resubstitution classification	Leave-one-out cross	Wilks lambda
Genes	Matrix	Validation	Matrix	Validation	Value	f	p value
Bcl2, BLR1, FcγR1A, R1A, IFNγ, IL4δ2	95.65	91.3	95.83	95.83	0.74	14	<0.001
Bcl2, FcγR1A, IFNγ, IL4δ2, MARCO	91.3	91.3	95.83	91.66	0.72	15.8	<0.001
Bcl2, BLR1,CD163, FcγR1A, IL4δ2	95.65	95.65	91.66	87.5	0.75	13.65	<0.001
Bcl2, BLR1, FcγR1A, IL4δ2, MARCO	95.65	95.65	95.83	91.66	0.73	14.95	<0.001
Bcl2, CD19, FcγR1A, IL4δ2, MARCO	95.65	95.65	91.66	91.66	0.75	13.21	<0.001
Bcl2, BLR1, CD19, FcγR1A, IL4δ2	91.3	91.3	95.83	87.5	0.77	11.98	0.0013
Bcl2, BPI, FcγR1A, IL4δ2, MARCO	95.65	95.65	91.66	95.83	0.72	16.11	<0.001
BLR 1, FcγR1A, IFNγ, IL4δ2, MMp9	95.65	86.95	95.83	91.66	0.75	13.46	<0.001
BLR 1, FcγR1A, IFNγ, IL4d2, RAB13	91.3	86.95	95.83	91.66	0.76	13.13	<0.001
BLR2, FcγR1A, IL4δ2, MARCO, SPP1	95.65	95.65	95.83	87.5	0.71	16.7	<0.001

Percentage indicates the proportion of groups discriminated using the combination of markers; and f is the measure of fit.

ISSN: 1471-2334