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Table 2 General discriminate analysis of five marker combinations to discriminate active TB and household contacts

From: Combination of gene expression patterns in whole blood discriminate between tuberculosis infection states

 

Household contacts

TB cases

   
 

Resubstitution classification

Leave-one-out cross

Resubstitution classification

Leave-one-out cross

Wilks lambda

  

Genes

Matrix

Validation

Matrix

Validation

Value

f

p value

Bcl2, BLR1, FcγR1A, R1A, IFNγ, IL4δ2

95.65

91.3

95.83

95.83

0.74

14

<0.001

Bcl2, FcγR1A, IFNγ, IL4δ2, MARCO

91.3

91.3

95.83

91.66

0.72

15.8

<0.001

Bcl2, BLR1,CD163, FcγR1A, IL4δ2

95.65

95.65

91.66

87.5

0.75

13.65

<0.001

Bcl2, BLR1, FcγR1A, IL4δ2, MARCO

95.65

95.65

95.83

91.66

0.73

14.95

<0.001

Bcl2, CD19, FcγR1A, IL4δ2, MARCO

95.65

95.65

91.66

91.66

0.75

13.21

<0.001

Bcl2, BLR1, CD19, FcγR1A, IL4δ2

91.3

91.3

95.83

87.5

0.77

11.98

0.0013

Bcl2, BPI, FcγR1A, IL4δ2, MARCO

95.65

95.65

91.66

95.83

0.72

16.11

<0.001

BLR 1, FcγR1A, IFNγ, IL4δ2, MMp9

95.65

86.95

95.83

91.66

0.75

13.46

<0.001

BLR 1, FcγR1A, IFNγ, IL4d2, RAB13

91.3

86.95

95.83

91.66

0.76

13.13

<0.001

BLR2, FcγR1A, IL4δ2, MARCO, SPP1

95.65

95.65

95.83

87.5

0.71

16.7

<0.001

  1. Percentage indicates the proportion of groups discriminated using the combination of markers; and f is the measure of fit.