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Table 1 The IC 50 of 5 viruses and FC contrasted with pNL4-3 W T

From: Impact of Y181C and/or H221Y mutation patterns of HIV-1 reverse transcriptase on phenotypic resistance to available non-nucleoside and nucleoside inhibitors in China

Virus IC50 a ± SD (nM) (FCb)
NVP EFV AZT 3TC d4T
WTpNL4–3 74.49 ± 9.24 (1.0) 13.66 ± 7.74 (1.0) 21.42 ± 16.84 (1.0) 44.60 ± 31.99 (1.0) 275.20 ± 118.69(1.0)
K101Q/Y181C/H221Y 93400.00 ± 32831.88*(1253.9) 68.33 ± 12.95*(5.0) 40.90 ± 13.55 (1.9) 102.38 ± 30.42 (2.3) 727.55 ± 157.47 (1.9)
K101Q/Y181C 73470.00 ± 20855.22*(986.4) 40.46 ± 15.70 (3.0) 10.26 ± 4.34 (0.5) 79.17 ± 3.56 (1.2) 373.33 ± 214.30 (1.4)
K101Q/H221Y 294.63 ± 80.62 (4.0) 0.54 ± 0.32*(0.04) 222.10 ± 49.35*(10.4) 496.8 ± 115.53*(11.1) 5715.00 ± 610.50*(20.8)
K101Q 56.63 ± 11.36 (0.8) 5.17 ± 1.44 (0.4) 52.34 ± 11.93 (2.4) 82.58 ± 62.18 (1.9) 322.90 ± 119.67 (1.2)
  1. a, the 50% inhibitory concentration. b, calculated by dividing the IC50 of each mutant virus by the IC50 for the wild-type. The mean ± SD of three independent experiments. FC only showed the mean of three independent experiments. * IC50 was significantly change compared with pNL4-3 WT , P < 0.05.