Skip to main content

Table 3 Infant CD4, CD19 and CD8 parameters at 6 months of age

From: Impact of maternal HIV-1 viremia on lymphocyte subsets among HIV-exposed uninfected infants: protective mechanism or immunodeficiency

Maternal viral load

 

CD4 (mean, 95% CI)

p†

Adjusted CD4 (mean, 95% CI)

p‡

CD19 (mean, 95% CI)

p†

Adjusted CD19 (mean, 95% CI)

p‡

CD8 (mean, 95% CI)

p†

Adjusted CD8 (mean, 95% CI)

P‡

>1000

Relative*

42.1 (39.3–44.9)

0.009

40.1 (37.1–43.1)

<0.001

30.8 (27.9–33.7)

0.008

32.9 (29.8–36.1)

<0.001

15.2 (13.6–16.8)

0.99

14.9 (13.2–16.6)

0.73

 

Absolute**

2271 (1907–2635)

0.002

2290 (1893–2687)

0.022

1528 (1261–1794)

0.27

1712 (1420–2003)

0.73

828 (680–977

0.10

853 (690–1016)

0.95

50-1000

Relative

47.0 (44.5–49.4)

0.52

46.8 (44.3–49.2)

0.78

27.0 (24.5–29.6)

0.75

27.8 (25.2–30.4)

0.27

15.8 (14.4–17.1)

0.43

15.3 (13.9–16.7)

0.24

 

Absolute

2861 (2540–3181)

0.88

2876 (2550–3202)

0.96

1727 (1492–1961)

0.76

1788 (1549–2027)

0.32

937 (806–1068)

0.74

926 (792–1060)

0.68

<50

Relative

46.1 (45.1 – 47.1)

Ref

46.4 (45.4–47.4)

Ref

26.6 (25.5–27.6)

Ref

26.2 (25.2–27.3)

Ref

15.2 (14.6–15.7)

Ref

15.3 (14.7–15.8)

Ref

 

Absolute

2887 (2756–3017)

 

2878 (2747–3010)

 

1687 (1592–1783)

 

1656 (1559–1752)

 

961 (908–1014)

 

957 (903–1011)

 
  1. *Relative counts are reported as percentages.
  2. **Absolute counts are reported as cells/mm3.
  3. †Comparing means in group VL > 1000 and VL 50–1000 to VL < 50 (reference group) using sum of least squares.
  4. ‡Adjusted for maternal CD4, maternal ART use, infant ART use, gender, gestational age and race in a multivariable analysis of variance.