Skip to main content

Advertisement

Table 3 Infant CD4, CD19 and CD8 parameters at 6 months of age

From: Impact of maternal HIV-1 viremia on lymphocyte subsets among HIV-exposed uninfected infants: protective mechanism or immunodeficiency

Maternal viral load   CD4 (mean, 95% CI) p Adjusted CD4 (mean, 95% CI) p CD19 (mean, 95% CI) p Adjusted CD19 (mean, 95% CI) p CD8 (mean, 95% CI) p Adjusted CD8 (mean, 95% CI) P
>1000 Relative* 42.1 (39.3–44.9) 0.009 40.1 (37.1–43.1) <0.001 30.8 (27.9–33.7) 0.008 32.9 (29.8–36.1) <0.001 15.2 (13.6–16.8) 0.99 14.9 (13.2–16.6) 0.73
  Absolute** 2271 (1907–2635) 0.002 2290 (1893–2687) 0.022 1528 (1261–1794) 0.27 1712 (1420–2003) 0.73 828 (680–977 0.10 853 (690–1016) 0.95
50-1000 Relative 47.0 (44.5–49.4) 0.52 46.8 (44.3–49.2) 0.78 27.0 (24.5–29.6) 0.75 27.8 (25.2–30.4) 0.27 15.8 (14.4–17.1) 0.43 15.3 (13.9–16.7) 0.24
  Absolute 2861 (2540–3181) 0.88 2876 (2550–3202) 0.96 1727 (1492–1961) 0.76 1788 (1549–2027) 0.32 937 (806–1068) 0.74 926 (792–1060) 0.68
<50 Relative 46.1 (45.1 – 47.1) Ref 46.4 (45.4–47.4) Ref 26.6 (25.5–27.6) Ref 26.2 (25.2–27.3) Ref 15.2 (14.6–15.7) Ref 15.3 (14.7–15.8) Ref
  Absolute 2887 (2756–3017)   2878 (2747–3010)   1687 (1592–1783)   1656 (1559–1752)   961 (908–1014)   957 (903–1011)  
  1. *Relative counts are reported as percentages.
  2. **Absolute counts are reported as cells/mm3.
  3. Comparing means in group VL > 1000 and VL 50–1000 to VL < 50 (reference group) using sum of least squares.
  4. Adjusted for maternal CD4, maternal ART use, infant ART use, gender, gestational age and race in a multivariable analysis of variance.