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Table 2 Infant CD4, CD19 and CD8 parameters at 2 months of age

From: Impact of maternal HIV-1 viremia on lymphocyte subsets among HIV-exposed uninfected infants: protective mechanism or immunodeficiency

Maternal viral load

 

CD4 (mean, 95% CI)

p†

Adjusted CD4 (mean, 95% CI)

p‡

CD19 (mean, 95% CI)

p†

Adjusted CD19 (mean, 95% CI)

p‡

CD8 (mean, 95% CI)

p†

Adjusted CD8 (mean, 95% CI)

P‡

>1000

Relative*

44.3 (41.5–47.0)

0.007

43.5 (40.6–46.3)

0.001

28.7 (26.1–31.4)

0.003

29.3 (26.4–32.2)

0.001

15.5 (14.0–17.1)

0.90

16.0 (14.4–17.6)

0.58

 

Absolute**

2432 (2072–2792)

0.02

2395 (2009–2781)

0.022

1479 (1255–1703)

0.79

1510 (1272–1747)

0.49

849 (713–985)

0.26

868 (721–1015)

0.94

50–1000

Relative

48.7 (46.2–51.3)

0.74

48.6 (46.1–51.0)

0.99

23.8 (21.3–26.4)

0.65

24.2 (21.7–26.7)

0.96

15.8 (14.4–17.2)

0.68

15.6 (14.2–17.0)

0.73

 

Absolute

2872 (2533–3210)

0.94

2888 (2548–3229)

0.96

1375 (1165–1585)

0.53

1416 (1206–1625)

0.57

952 (824–1079)

0.77

947 (817–1077)

0.80

<50

Relative

48.3 (47.3–49.2)

Ref

48.5 (47.6–49.5)

Ref

24.5 (23.5–25.4)

Ref

24.1 (23.2–25.1)

Ref

15.4 (14.9–16.0)

Ref

15.5 (15.0–16.1)

Ref

 

Absolute

2884 (2759–3010)

 

2878 (2751–3005)

 

1446 (1369–1523)

 

1419 (1342–1497)

 

931 (884–979)

 

930 (882–979)

 
  1. *Relative counts are reported as percentages.
  2. **Absolute counts are reported as cells/mm3.
  3. †Comparing means in group VL > 1000 and VL 50–1000 to VL < 50 (reference group) using sum of least squares.
  4. ‡Adjusted for maternal CD4, maternal ART use, infant ART use, gender, gestational age and race in a multivariable analysis of variance.