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Table 1 Demographic characteristics of 84 patients with staphylococcal PVGI

From: Factors predictive of treatment failure in staphylococcal prosthetic vascular graft infections: a prospective observational cohort study: impact of rifampin

Population, n = 84 Remission Failure p
  n = 63, (%) n = 21, (%)  
Age, mean ± SD 64.1 ± 11 67.8 ± 12 0.2
Diabetes mellitus 19 (30.1) 6 (28.5) 0.89
Body mass index, mean ± SD 25 ± 4.7 26 ± 4.3 0.46
Creatinine clearance < 60 ml/min 15 (23.8) 9 (42.8) 0.09
Immunodepression 11 (17.4) 4 (19.1) 0.86
Chronic obstructive pulmonary disease 14 (22.2) 8 (38.1) 0.15
Coronary disease 35 (55.5) 13 (61.9) 0.61
Aortic aneurysm 20 (31.7) 12 (57.1) 0.03
Presumed PVGI 7 (11.1) 1 (4.7) 0.39
Definite PVGI 56 (88.9) 20 (95.2) 0.39
Early definite PVGI (<4 months) 30 (47.6) 12 (57.1) 0.45
Late definite PVGI (> 4 months) 26 (41.2) 8 (38.1) 0.79
Extracavitary PVGI 31 (49.9) 6 (29.6) 0.07
Fever > 38°C 37 (58.7) 19 (90.5) 0.009
Fissuration/disruption 7 (11.1) 2 (9.5) 0.02
False aneurysm 9 (14.2) 2 (9.5) 0.6
White blood cells count (G/l) 11.196 ± 4.6 11.022 ± 3.48 0.88
Mean ± SD
Autologous vein 10 (15.8) 2 (9.5) 0.47
Arterial homo/allograft 20 (31.7) 4 (19) 0.26
New prosthesis 6 (9.5) 2 (9.5) 1
Debridement 16 (25.4) 8 (38.1) 0.26
Medical treatment (no surgery) 9 (9.5) 4 (19) 0.6
Adequate empirical antibiotherapy 60 (95.2) 19 (90.4) 0.42
New surgery 15 (23.8) 10 (47.6) 0.02
Rifampin combination 38 (60.3) 7 (33.3) 0.03
Admission to intensive care unit 21 (33.3) 14 (66.6) 0.007
Septic shock at initial presentation 7 (11.1) 8 (38.1) 0.005
Post-operative dialysis 0 (0) 4 (19) 0.001
Death related to PVGI 0 (0) 14 (66.6) 0.001
Death not related to PVGI 6 (9.5) 2 (9.5) 1
Median follow-up (interquartile) (days) 605 ± 406 621 ± 455 0.2
  1. PVGI: Prosthetic vascular graft infection. MSSA: Methicillin-susceptible Staphylococcus aureus; MRSA: Methicillin-resistant Staphylococcus aureus; CNS, Coagulase-negative staphylococci.