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Figure 2 | BMC Infectious Diseases

Figure 2

From: Diagnostic and prognostic utilities of multimarkers approach using procalcitonin, B-type natriuretic peptide, and neutrophil gelatinase-associated lipocalin in critically ill patients with suspected sepsis

Figure 2

Comparison of BNP and NGAL according to the subscores of SOFA score. (A) The BNP concentrations according to the cardiovascular subscore of SOFA score were: 245.5 (5 – 2,140) pg/mL; 43 (1 – 5,000) pg/mL; 223.9 (12.6 – 1,260) pg/mL; 245 (13.5 – 1,850) pg/mL; and 257 (10.1 – 609) pg/mL, respectively. The BNP concentration was significantly associated with the cardiovascular subscore of SOFA score (P < 0.0001). (B) The BNP concentrations according to the respiratory subscore of SOFA score were: 180 (35 – 1,240) pg/mL; 232.5 (5 – 1,370) pg/mL; 281 (5 – 2,140) pg/mL; 43 (5 – 3,070) pg/mL; and 46.6 (5 – 5,000) pg/mL, respectively. Although the BNP concentration was significantly different according to the respiratory subscore of SOFA score, there was no increasing tendency (P < 0.0001). (C) The BNP concentrations according to the renal subscore of SOFA score were: 43.7 (5 – 3,070) pg/mL; 147 (5 – 5,000) pg/mL; 266.5 (5 – 4,900) pg/mL; 211.5 (5 – 5,000) pg/mL; and 1,220 (19.4 – 3,170) pg/mL, respectively. The BNP concentration was significantly associated with the renal subscore of SOFA score (P < 0.0001). (D) The NGAL concentrations according to the renal subscore of SOFA score were: 137 (16 – 1,301) ng/mL; 234 (33 – 1,300) ng/mL; 612 (59 – 1,301) ng/mL; 1015.5 (127 – 1,300) ng/mL; and 1,300 (444 – 1,300) ng/mL, respectively. The NGAL concentration was significantly associated with the renal subscore of SOFA score (P < 0.0001). Abbreviations: BNP, B-type natriuretic peptide; NGAL, neutrophil gelatinase-associated lipocalin; SOFA, sepsis-related organ failure assessment.

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