|
Age (years)
|
N
|
% pgp3 Ab + after 6 mos (CI)
|
P-value
|
N
|
% CT694 Ab + after 6 mos (CI)
|
P-value
|
|---|
| | |
IgG
|
0.06
| | |
0.28
|
|
1
|
8
|
22.24 (4.24, 40.25)
|
0.01
|
8
|
36.89 (10.46, 63.32)
|
0.002
|
|
2
|
5
|
9.64 (−13.14, 32.41)
|
0.83
|
6
|
32.25 (1.73, 62.77)
|
0.03
|
|
3
|
14
|
4.94 (−8.67, 18.54)
|
0.91
|
15
|
18.36 (−0.94, 37.67)
|
0.07
|
|
4
|
22
|
9.07 (−1.79, 19.93)
|
0.15
|
23
|
15.59 (0.00, 31.18)
|
0.05
|
|
5
|
30
|
12.01 (2.72, 21.31)
|
0.005
|
28
|
16.40 (2.27, 30.53)
|
0.01
|
|
6
|
26
|
4.01 (−5.98, 14.00)
|
0.86
|
25
|
0.60 (−14.36, 15.55)
|
1.00
|
| | |
IgA
|
0.003
| | |
0.0006
|
|
1
|
7
|
60.08 (31.36, 88.80)
|
<0.0001
|
6
|
75.06 (40.00, 100.00)
|
<0.0001
|
|
2
|
5
|
60.11 (26.12, 94.10)
|
<0.0001
|
4
|
68.85 (25.90, 100.00)
|
0.0003
|
|
3
|
12
|
47.91 (25.97, 69.85)
|
<0.0001
|
10
|
34.25 (7.08, 61.41)
|
0.01
|
|
4
|
14
|
41.91 (21.60, 62.22)
|
<0.0001
|
11
|
30.93 (5.03, 56.83)
|
0.01
|
|
5
|
23
|
45.52 (29.67, 61.37)
|
<0.0001
|
20
|
53.66 (34.45, 72.87)
|
<0.0001
|
|
6
|
20
|
52.53 (35.53, 69.52)
|
<0.0001
|
17
|
53.01 (32.17, 73.84)
|
<0.0001
|
- Values show the mean percentage drop in antibody median fluorescence intensity-background (MFI-BG) for IgG (top section) and IgA (bottom) from baseline to 6 months after drug treatment in paired samples. 95% confident intervals are shown in parentheses. P values testing for a difference from zero (no change) of < 0.05 were considered significant. P values in bold test for an average difference from zero across all age groups.
