Table 5 Comparison of pyrosequencing and Bactec MGIT 960 DST
Drugs and specimen | Pyro. methods | No. of samples by Bactec 960 method | Mean% (95% CI) | Â | |||
|---|---|---|---|---|---|---|---|
Clinical isolates | Â | R | S | Sensitivity | Specificity | Accuracy | Kappa |
RIF | R | 152 | 1 | 94.4 | 97.6 | 95.0 | 0.86 |
| Â | S | 9 | 40 | 89.7-97.0 | 87.4-99.6 | Â | Â |
INH | R | 128 | 0 | 75.3 | 100 | 79.2 | 0.49 |
| Â | S | 42 | 32 | 68.3-81.2 | 89.3-100.0 | Â | Â |
SM | R | 107 | 3 | 79.3 | 95.4 | 84.5 | 0.68 |
| Â | S | 28 | 62 | 71.7-85.2 | 87.3-98.4 | Â | Â |
EMB | R | 71 | 10 | 58.7 | 87.7 | 70.3 | 0.43 |
| Â | S | 50 | 71 | 49.8-67.1 | 78.7-93.2 | Â | Â |
OFL | R | 108 | 1 | 86.4 | 98.7 | 91.1 | 0.82 |
| Â | S | 17 | 77 | 79.3-91.3 | 93.1-99.8 | Â | Â |
AMK | R | 32 | 0 | 82.1 | 100 | 96.5 | 0.88 |
| Â | S | 7 | 159 | 67.3-91.0 | 97.6-100.0 | Â | Â |
Sputum samples | Â | Â | Â | Â | Â | Â | Â |
RIF | R | 15 | 1 | 83.3 | 83.3 | 83.3 | 0.6 |
| Â | S | 3 | 5 | 60.8-94.2 | 43.7-97.0 | Â | Â |
INH | R | 13 | 0 | 76.5 | 100 | 83.3 | 0.66 |
| Â | S | 4 | 7 | 52.7-90.4 | 64.6-100.0 | Â | Â |
SM | R | 11 | 0 | 73.3 | 100 | 83.3 | 0.67 |
| Â | S | 4 | 9 | 48.1-89.1 | 70.0-100.0 | Â | Â |
EMB | R | 5 | 2 | 41.7 | 81.8 | 60.9 | 0.23 |
| Â | S | 7 | 9 | 19.3-68.1 | 52.3-94.9 | Â | Â |
OFL | R | 13 | 0 | 86.7 | 100 | 91.7 | 0.83 |
| Â | S | 2 | 9 | 62.1-96.3 | 70.1-100.0 | Â | Â |
AMK | R | 2 | 0 | 40 | 100 | 87.5 | 0.51 |
| Â | S | 3 | 19 | 11.8-76.9 | 83.2-100.0 | Â | Â |