Table 3 Mutations of the rpoB gene identified by pyrosequencing in clinical isolates and sputum samples

L511P

CTG/CCG

1

1

Q513H

CAA/CAC

1

D516N

GAC/AAC

1

D516A

GAC/GCC

1

D516G

GAC/GGC

3

D516V

GAC/GTC

5

D516Y

GAC/TAC

1

1

D516F

GAC/TTC

1

N518S

AAC/AGC

1

H526N

CAC/AAC

4

H526Q

CAC/CAG

1

H526R

CAC/CGC

2

H526D

CAC/GAC

9

H526Y

CAC/TAC

6

H526C

CAC/TGC

5

H526F

CAC/TTC

1

S531T

TCG/ACG

2

S531Y

TCG/TAT

2

S531W

TCG/TGG

5

S531L

TCG/TTG

92

L533P

CTG/CCG

1

L533R

CTG/CGG

4

Q510H + H526Y

CAG/CAC + CAC/TAC

1

L511P + D516G

CTG/CCG + GAC/GGC

1

L511P + Q513P

CTG/CCG + CAA/CCA

1

L511P + D516G + N518S

CTG/CCG + GAC/GGC + AAC/GAC

1

N518S + H526P

AAC/AGC + CAC/CCC

1

S512T + D516G

AGC/ACG + GAC/GGC

1

D516A + L533P

GAC/GCC + CTG/CCG

1

H526N + L533P

CAC/AAC + CTG/CCG

1

H526Q + L533P

CAC/CAG + CTG/CCG

1

H526Y + S531T + L530R

CAC/TAC + TCG/ACG + CTG/CGT

1

L511P + S531L

CTG/CCG + TCG/TTG

1

D516A + S531L

GAC/GCC + TCG/TTG

1

D516V + S531L

GAC/GTC + TCG/TTG

1

S531L + L533R

TCG/TTG + CTG/CGG

1

H526D + L533R

CAC/GAC + CTG/CGG

1

H526Y + L533R

CAC/TAC + CTG/CGG

1

S531L + L533S

TCG/TTG + CTG/TCG

2

WT

12

45

Fail

3