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Table 3 Long-term protection in mice immunized with inactivated vaccine with or without adjuvant a

From: An adjuvanted inactivated murine cytomegalovirus (MCMV) vaccine induces potent and long-term protective immunity against a lethal challenge with virulent MCMV

Immunogen Dosage (μg) ELISA titer (2n) of IgG antibodyb(6 months after the last immunization) Protection against SGV challenge
Survival mice/total mice
Adjuvant-free 4 8.0 ± 0.8 3/14
+Chitosan   9.5 ± 1.0d 6/14c
+Alum   11.7 ± 0.5d 12/14c,d
+MF59   12.3 ± 0.6d 13/14c,d
PBS - - 1/15
  1. aMice were immunized by i.p. injection twice, 3 weeks apart, with 4 μg of the inactivated vaccine with or without an adjuvant (MF59, alum, or chitosan). Mice were challenged with a lethal dose of SG-MCMV 6 months after the last immunization. Serum samples from the immunized mice were collected 2 days prior to challenge. The survival of mice 3 weeks after the challenge was measured.
  2. bValues represent means ± SD of each group.
  3. cSignificant difference (p < 0.05), compared with control.
  4. dSignificant difference (p < 0.05), compared with the corresponding adjuvant-free subjects.
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BMC Infectious Diseases

ISSN: 1471-2334

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