An adjuvanted inactivated murine cytomegalovirus (MCMV) vaccine induces potent and long-term protective immunity against a lethal challenge with virulent MCMV

Table 2 Survival after lethal SG-MCMV challenge in mice immunized intraperitoneally with various doses of inactivated vaccine with or without adjuvant ^a

Immunogen	Protection against SGV challenge (Survival mice/total mice) by various doses of FI-MCMV immunization
Immunogen	-	0.25 μg	1 μg	4 μg
Adjuvant-free	0/6	0/6	0/6	2/6
+ Chitosan	0/6	0/6	2/6	6/6^*
+ Alum	0/6	0/6	4/6	6/6^*
+ MF59	0/6	5/6^*	6/6^*	6/6^*
Mock	0/6	-	-	-
PBS	0/6	-	-	-

^aThe mice were immunized twice, 3 weeks apart, with various doses (0.25, 1, or 4 μg) of the vaccine with or without adjuvant (MF59, alum, or chitosan) by i.p. injection. The mice were challenged with a lethal dose of SG-MCMV 3 weeks after the second immunization. Mouse survival 3 weeks after challenge was measured.
*Significant difference (p < 0.05), compared with control subjects.

ISSN: 1471-2334