|
Immunogen
|
Protection against SGV challenge (Survival mice/total mice) by various doses of FI-MCMV immunization
|
|---|
|
-
|
0.25 μg
|
1 μg
|
4 μg
|
|---|
|
Adjuvant-free
|
0/6
|
0/6
|
0/6
|
2/6
|
|
+ Chitosan
|
0/6
|
0/6
|
2/6
|
6/6*
|
|
+ Alum
|
0/6
|
0/6
|
4/6
|
6/6*
|
|
+ MF59
|
0/6
|
5/6*
|
6/6*
|
6/6*
|
|
Mock
|
0/6
|
-
|
-
|
-
|
|
PBS
|
0/6
|
-
|
-
|
-
|
-
aThe mice were immunized twice, 3 weeks apart, with various doses (0.25, 1, or 4 μg) of the vaccine with or without adjuvant (MF59, alum, or chitosan) by i.p. injection. The mice were challenged with a lethal dose of SG-MCMV 3 weeks after the second immunization. Mouse survival 3 weeks after challenge was measured.
- *Significant difference (p < 0.05), compared with control subjects.
