Table 1 Antibody titers in sera of mice immunized with various doses of FI-MCMV with or without adjuvant by i.p. injection and viral loads in mouse organs after lethal viral challenge ^a

Adjuvant-free

0.25

3.33 ± 0.58

5.67 ± 0.52

5.16 ± 0.22

Not done^f

+ Chitosan

5.83 ± 1.17^c

9.83 ± 1.17^c

5.12 ± 0.28^e

Not done

+ Alum

6.67 ± 1.63^c

11.17 ± 0.98^c

5.06 ± 0.21^e

Not done

+ MF59

7.50 ± 1.52^c

12.83 ± 1.47^c,d

4.06 ± 0.62^c,d,e

4.76 ± 0.48

Adjuvant-free

1

5.33 ± 0.58

9.17 ± 0.98

5.03 ± 0.40^e

Not done

+ Chitosan

6.67 ± 1.15

12.67 ± 1.03^c

4.83 ± 0.12^e

5.46 ± 0.57

+ Alum

7.83 ± 0.98^c

14.00 ± 0.63^c

4.31 ± 0.83^e

5.12 ± 0.91

+ MF59

11.33 ± 0.82^c,d

15.33 ± 1.03^c,d

3.45 ± 0.56^c,e

4.34 ± 0.42

Adjuvant-free

4

8.67 ± 0.82

11.67 ± 1.03

4.85 ± 0.21^e

5.70 ± 0.38

+ Chitosan

10.50 ± 0.55^c

14.83 ± 1.17^c

3.95 ± 0.48^c,e

4.57 ± 0.74^c

+ Alum

11.00 ± 0.89^c

15.17 ± 0.41^c

3.61 ± 0.66^c,e

4.10 ± 0.27^c

+ MF59

12.17 ± 0.75^c

17.00 ± 1.10^c,d

2.08 ± 0.81^c,d,e

2.31 ± 0.43^c,d

Chitosan only

-

Undetected

Undetected

5.76 ± 0.29

Not done

Alum only

Undetected

Undetected

5.83 ± 0.38

Not done

MF59 only

Undetected

Undetected

5.74 ± 0.18

Not done

Mock

Undetected

Undetected

5.61 ± 0.36

Not done

PBS

-

-

5.94 ± 0.25

Not done