Clinical characteristics and outcomes in critical patients with hemorrhagic fever with renal syndrome

BMC Infectious Diseases

Table 6 Laboratory parameters in critical patients with HFRS during the acute stage

Variables	Survivors (n = 46)		Non-survivors (n = 29)		P value^a
Variables	Mean ± SD	n^b	Mean ± SD	n^b	P value^a
Maximum WBC, 10⁹ cells/L	34.43 ± 16.02^c	39	47.95 ± 21.78^c	26	.005
Nadir PLT, 10⁹ cells/L	12.18 ± 11.16^d	39	14.35 ± 10.28^d	26	.432
Maximum HGB, g/L	171.00 ± 24.11^c	39	166.92 ± 26.42^c	25	.162
Maximum ALT, u/L	170.11 ± 210.92^c	44	502.91 ± 859.69^c	29	.213
Nadir serum ALB, g/L	24.53 ± 4.92^d	44	22.45 ± 5.20^d	29	.088
Maximum BUN, mmol/L	31.13 ± 8.58^c	44	26.34 ± 12.77^c	29	.084
Maximum Scr, μmol/L	778.46 ± 220.86^c	44	479.66 ± 254.29^c	29	<.001
Maximum glucose, mmol/L	13.32 ± 6.00^c	43	15.34 ± 8.22^c	28	.235
Longest PT, sec	15.20 ± 3.44^c	45	20.53 ± 9.15^c	28	.006
Longest APTT, sec	45.96 ± 14.79^c	45	59.52 ± 19.94^c	28	.003
Longest TT, sec	23.86 ± 6.24^c	45	25.32 ± 6.72^c	28	.282
Minimum Fib, g/L	1.84 ± 0.82^d	44	1.46 ± 0.84^d	29	.056

Reference values: WBC (3.2-9.7) × 10⁹/L; PLT (100–300) × 10⁹/L; HGB (120–160) g/L (male), (110–150) g/L (female); ALT (4–44) U/L; serum ALB (35–55) g/L; serum BUN (2.86-8.20) mmol/L; serum Cr (53–97) μmol/L (male), (35–71) μmol/L (female); glucose (3.89-6.11) mmol/L; PT (8.8-13.8) sec; APTT (25.1-36.5) sec; TT (10.3-16.6) sec, Fib (2.38-4.98) g/L.
Abbreviations: WBC, white blood cells; PLT, platelet; HGB, hemoglobin; ALT, alanine aminotransferase; ALB, albumin; BUN, blood urea nitrogen; Scr, serum creatinine; PT, prothrombin time; APTT, activated partial thromboplastin time; TT, thrombin time; Fib, fibrinogen.
^aSurvivors vs. non-survivors.
^bSome critical patients had passed through the acute stage on admission, and therefore, no laboratory data were available.
^cHigher or longer than the reference value, P < .001.
^dLower than the reference value, P < .001.

ISSN: 1471-2334