Table 2 Cox proportional hazards analysis of factors associated with the emergence of hepatotoxicity of any grade
Variable | Univariate analysis | Multivariable analysis | ||
|---|---|---|---|---|
Hazard ratio (95% CI) | P value | Hazard ratio ( 95% CI) | P value | |
Age (per 1-year increase) | 1.021 (0.987-1.057) | 0.230 | 1.025 (0.990-1.061) | 0.162 |
CD4+ cell count (>250/mm3 vs ≤ 250/mm3) | 1.257 (0.853-1.851) | 0.247 | 1.397 (0.940-2.075) | 0.098 |
Hemoglobin (<median level of 10.3 g/dl vs ≥ median) | 1.275 (0.897-1.811) | 0.176 | 1.320 (0.924-1.886) | 0.128 |
Presence of HBV or HCV infection | 1.788 (1.041-3.073) | 0.035 | 1.797 (1.042-3.098) | 0.035 |