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Table 1 Studies documenting duration of MRSA colonization meeting inclusion criteria

From: Natural history of colonization with methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus(VRE): a systematic review

Author year [ref] Study ID Design Country Year of study Subject description Screening site Screening method Latest documented follow up (weeks) N Lost to follow up (N) Clearance defined Weeks to documented clearance % cleared
Sanford 1994 [11] A Retrospective cohort USA 1989-1991 Hospitalized patients Nares, axillae, perineum/ groin, wound, sputum, tracheal aspirate CX; T 240 36 * 2 negative CX 172 50%†
Mulhausen 1996 [12] B Prospective cohort USA 1991-2 Residents at LTCFs Nares CX 52 47 34 1 negative CX on two separate samplings 52 13%
O’Sullivan 2000 [13] C Prospective cohort Ireland 1994-5 Residents at LTCFs Nares, throat, hairline, axillae, groin, perineum, skin lesions CX; T 39 65 14 1 negative CX 26 49%
Scanvic 2001 [14] D Prospective cohort France 1998 Hospitalized patients Nares, skin, axillae, groin CX; T 36 (a) 78 * 4 negative CX obtained from 2 sites 37 50%†
Ellis 2004 [15] E Prospective cohort USA 2003 US Army personnel Nares CX; T 13 24 * 1 negative CX 9 67%
Cretnik 2005 [16] F Prospective cohort Slovenia 2001-2 Residents and HCW at LTCFs Nares, skin lesions, axillae, groin CX; T 13 12 2 2 negative CX from 2 sites on 3 separate samplings 13 33%
Vriens 2005 [17] G Prospective cohort Netherlands 1991-2001 Hospitalized patients Nares, throat, perineum, wounds, skin lesions, urine and sputum CX; PCR 104 57 21 All negative CX from up to 7 sites on 3 separate samplings 104 46%
Marschall 2006 [18] H Retrospective cohort Switzerland 2000-3 Hospitalized patients Nares, groin, skin lesions, tracheal secretions, urine CX; T 231 80 * All negative CX from up to 6 sites on 2 separate samplings 85 50%†
Ellis 2007 [19] I RCT USA 2005 US Army personnel Nares CX; T 16 66 1 1 negative CX 16 64%
Simor 2007 [20] J RCT Canada 2000-3 Hospitalized patients Nares, perineum, skin lesions, catheter sites CX; T 34 35 26 1 negative CX on 2 separate samplings 13 23%
Wendt 2007 [21] K RCT Germany 2001-4 Hospitalized patients and residents at LTCFs Nares, throat, groin, perineum, skin defects, any previously colonized site CX; T 13 58 3 All negative CX at up to 7 sites on 5 separate samplings 4 12%
Lucet 2009 [22] L Prospective cohort France 2003-4 Hospitalized patients discharged to home care Nares, chronic skin lesions CX 52 148 44 1 negative CX on 2 separate samplings 52 51%
Robicsek 2009 [23] M Retrospective cohort USA 2006-7 Hospitalized patients Nares PCR 208 824 * 1 negative PCR 208 79%
Lautenbach 2010 [24] N Prospective cohort USA 2008 Ambulatory patients and household contacts Nares, axilla, throat; groin and perineum CX; PCR; T 14 11 0 All negative cultures from up to 5 sites on 6 separate collections 14 73%
Manzur 2010 [25] O Prospective cohort Spain 2005-7 Residents at LTCFs Nares, decubitus ulcers CX; T 77 231 104 1 negative CX on 2 separate collections 77 27%
Van Velzen 2011 [26] P Retrospective cohort Scotland 2010 Hospitalized patients Nares, perineum, axillae, throat, wounds and devices CX; PCR; T 4 32 0 All negative cultures from up to 6 sites on 2 separate occasions 1 25%
  1. (a) Follow up at least 13 weeks since hospitalization; median clearance at 37 weeks reported; mean time since hospital discharge 36 weeks.
  2. *Not documented; † Kaplan Meier estimates which do not provide information on those lost to follow up.
  3. HCW: health care worker; LTCF: long term care facility; MRSA: methicillin resistant Staphylococcus aureus; N: number; CX: culture; T: typing of strain performed; PCR: polymerase chain reaction; RCT: randomized controlled trial.