From: Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series
IFN-γ treated patients | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
Age | Pathogens | n= | Site of nfection | n= | Underlying illness | n= | Antifungal therapy | n= | Outcome | n= |
49.6 ± SD19.8 | C. albicans | 3 | Candidaemia | 2 | Stem cell transplantation for AML | 1 | Anidulafungin | 1 | Cured without further infectious complications | 2 |
BMI | Candida spp | 2 | Candidaemia Endocarditis | 1 | Sarcoidosis treated with prednisone and azathioprin | 1 | Fluconazole | 1 | Lost to follow up after discharge from hospital | 1 |
22.9 ± SD6.9 | A. fumigatus | 2 | Pulmonary aspergilllosis | 3 | First remission induction chemotherapy for AML | 1 | L-AMB + Voriconazole | 1 | Slight reduction hepatic lesions | 1 |
Gender | C. tropicalis | 1 | Osteomeyelitis | 1 | ICD, Streptococcus sanguis endocarditis, aorta valve replacement with bioprosthesis | 1 | Voriconazole + Anidulafungin | 1 | Cured but complicated with mycotic cerebral aneurysms | 1 |
F: 5 M: 3 | A. fumigatus+ M. genavese | 1 | Hepatic abcess | 1 | persistent pulmonary cavity after radiotherapy for a T1N0M0 lungcarcinoma | 1 | Itraconasole, L-AMB, Voriconazole | 1 | Cured from candidemia episode, 4 months later unrelated bacterial sepsis episode | 1 |
 |  |  |  |  | Total parenteral nutrition via Hickmann catheter because of slow transit bowel, intestinal pseudo obstruction, or gastroparesis | 3 | Anidulafungin and step down to fluconazol | 3 | Died due to infectious complications 71 or 15 days after initiation of IFN-γ therapy | 2 |
Placebo treated patients | ||||||||||
53.0 ± SD19.1 | C. glabrata | 2 | Candidaemia | 3 | Total parenteral nutrition via Hickmann catheter because of slow transit bowel | 1 | Anidulafungin | 2 | Cured without further infectious complications | 3 |
BMI | C. tropicalis | 1 | Â | Â | HIV with porth-a-cath for venous access | 1 | Anidulafungin + amphotericin B | 1 | Â | Â |
18.5 ± SD4.0 |  |  |  |  | construction of ileal conduit urinary diversion (Bricker deviation) because of pT4N2M1 bladder cancer. | 1 |  |  |  |  |
Gender | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
F: 3 M: 0 | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |