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Table 1 Summary of clinical characteristics of all patients with invasive fungal infections

From: Interferon-gamma as adjunctive immunotherapy for invasive fungal infections: a case series

IFN-γ treated patients

Age

Pathogens

n=

Site of nfection

n=

Underlying illness

n=

Antifungal therapy

n=

Outcome

n=

49.6 ± SD19.8

C. albicans

3

Candidaemia

2

Stem cell transplantation for AML

1

Anidulafungin

1

Cured without further infectious complications

2

BMI

Candida spp

2

Candidaemia Endocarditis

1

Sarcoidosis treated with prednisone and azathioprin

1

Fluconazole

1

Lost to follow up after discharge from hospital

1

22.9 ± SD6.9

A. fumigatus

2

Pulmonary aspergilllosis

3

First remission induction chemotherapy for AML

1

L-AMB + Voriconazole

1

Slight reduction hepatic lesions

1

Gender

C. tropicalis

1

Osteomeyelitis

1

ICD, Streptococcus sanguis endocarditis, aorta valve replacement with bioprosthesis

1

Voriconazole + Anidulafungin

1

Cured but complicated with mycotic cerebral aneurysms

1

F: 5 M: 3

A. fumigatus+ M. genavese

1

Hepatic abcess

1

persistent pulmonary cavity after radiotherapy for a T1N0M0 lungcarcinoma

1

Itraconasole, L-AMB, Voriconazole

1

Cured from candidemia episode, 4 months later unrelated bacterial sepsis episode

1

     

Total parenteral nutrition via Hickmann catheter because of slow transit bowel, intestinal pseudo obstruction, or gastroparesis

3

Anidulafungin and step down to fluconazol

3

Died due to infectious complications 71 or 15 days after initiation of IFN-γ therapy

2

Placebo treated patients

53.0 ± SD19.1

C. glabrata

2

Candidaemia

3

Total parenteral nutrition via Hickmann catheter because of slow transit bowel

1

Anidulafungin

2

Cured without further infectious complications

3

BMI

C. tropicalis

1

  

HIV with porth-a-cath for venous access

1

Anidulafungin + amphotericin B

1

  

18.5 ± SD4.0

    

construction of ileal conduit urinary diversion (Bricker deviation) because of pT4N2M1 bladder cancer.

1

    

Gender

          

F: 3 M: 0

          
  1. F, female; M, male; ICD, implantable cardioverter-defribillator; HIV, human immunodeficiency virus; L-AMB, liposomal amphotericin B; BAL, bronchoalveolar lavage; AML, acute myeloid leukemia.