Risk factors for mortality in patients with Pseudomonas aeruginosa bacteremia; retrospective study of impact of combination antimicrobial therapy

Table 2 Risk factors associated with 14-day mortality in patients with P. aeruginosa bacteremia

	Univariate analysis			Multivariate analysis
Risk factor	OR	95% CI	Pvalue	OR	95% CI	Pvalue
Age > 60 (years)	1.42	0.77-2.64	0.26
Neutropenia	2.14	1.09-4.22	0.03	1.45	0.63-3.33	0.37
Mechanical ventilator	8.85	3.94-19.88	0.0001	6.93	2.64-18.11	0.0001
Central venous catheter	4.46	2.29-8.67	0.0001	2.95	1.35-6.43	0.007
APACHE II score ≥ 13	8.88	4.06-19.38	0.0001	4.65	1.95-11.04	0.0001
Septic shock	5.08	2.63-9.83	0.0001	2.91	1.33-6.38	0.007
Carbapenem resistance	1.02	0.55-1.89	0.94
Multidrug resistance	3.65	0.72-18.67	0.12
Pneumonia as a source of bacteremia	1.01	0.51-2.01	0.96
Empirical therapy
Appropriate combination therapy	0.82	0.31-2.14	0.69
Appropriate monotherapy	1.17	0.59-2.28	0.64
Inappropriate therapy	1.0 (ref)
Targeted therapy
Appropriate combination therapy	0.44	0.37-1.61	0.49
Appropriate monotherapy	0.78	0.15-1.27	0.13
Inappropriate therapy	1.0 (ref)

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