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Table 2 GMTs of sera pools tested with different JEV

From: Immune response to live-attenuated Japanese encephalitis vaccine (JE-CV) neutralizes Japanese encephalitis virus isolates from South-East Asia and India

Pool details JEV PRNT50neutralization results
Sample no. Pooled sera samples titer categorya JEV-SM1b JE-057434b JE-902/97b TVP-8236c JE-CVc SA14-14-2c JE Nakayamac Sample overall GMT
1 Low 84
(68–103)
165
(64–423)
94
(83–106)
130
(71–240)
65
(46–91)
39
(8–181)
182
(62–533)
96
(74–126)
2 Low 98
(86–111)
108
(45–258)
90
(65–125)
82
(70–96)
112
(54–231)
59
(41–84)
113
(51-252)
93
(81–106)
3 Medium 167
(84–332)
361
(235–554)
181
(114–286)
157
(97–254)
200
(111–360)
98
(41–232)
344
(136–872)
197
(158–246)
4 Medium 160
(84–305)
369
(225–604)
163
(124–214)
148
(80–276)
388
(167–899)
126
(81–196)
186
(81–429)
200
(161–249)
5 High 276
(150–508)
841
(380–1860)
155
(85–286)
253
(164–391)
780
(557–1092)
159
(71–355)
404
(192–851)
333
(244–456)
6 High 749
(539–1040)
766
(359–1634)
522
(419–649)
523
(348–788)
520
(205–1319)
299
(138–649)
474
(298–753)
529
(448–623)
7 Very high 517
(368–728)
1023
(600–1743)
346
(269–446)
638
(455–895)
2865
(1660–4945)
699
(609–803)
902
(788–1034)
801
(598–1074)
8 d Negative <10 <10 <10 <10 <10 <10 <10 <10
JEV Overall GMT 218
(152–313)
397
(271–584)
183
(138–244)
214
(154–300)
351
(201–613)
138
(89–214)
302
(218–418)
243
(209–282)
  1. GMTs are presented in bold font with 95% confidence intervals in parentheses.
  2. aResults from original study testing using JE-CV PRNT assay at Focus Diagnostics Ltd., US [22]; low = titer range 40–80, medium = titer range 160–320, high = titer range 640–2560, very high = titer range >5120., negative = <10.
  3. bRecent JEV isolate.
  4. cJEV isolate tested in previous clinical trials [5, 8].
  5. dSample 8 was not used in calculating overall (sample/JEV) GMT.