Skip to main content

Table 2 GMTs of sera pools tested with different JEV

From: Immune response to live-attenuated Japanese encephalitis vaccine (JE-CV) neutralizes Japanese encephalitis virus isolates from South-East Asia and India

Pool details

JEV PRNT50neutralization results

Sample no.

Pooled sera samples titer categorya

JEV-SM1b

JE-057434b

JE-902/97b

TVP-8236c

JE-CVc

SA14-14-2c

JE Nakayamac

Sample overall GMT

1

Low

84

(68–103)

165

(64–423)

94

(83–106)

130

(71–240)

65

(46–91)

39

(8–181)

182

(62–533)

96

(74–126)

2

Low

98

(86–111)

108

(45–258)

90

(65–125)

82

(70–96)

112

(54–231)

59

(41–84)

113

(51-252)

93

(81–106)

3

Medium

167

(84–332)

361

(235–554)

181

(114–286)

157

(97–254)

200

(111–360)

98

(41–232)

344

(136–872)

197

(158–246)

4

Medium

160

(84–305)

369

(225–604)

163

(124–214)

148

(80–276)

388

(167–899)

126

(81–196)

186

(81–429)

200

(161–249)

5

High

276

(150–508)

841

(380–1860)

155

(85–286)

253

(164–391)

780

(557–1092)

159

(71–355)

404

(192–851)

333

(244–456)

6

High

749

(539–1040)

766

(359–1634)

522

(419–649)

523

(348–788)

520

(205–1319)

299

(138–649)

474

(298–753)

529

(448–623)

7

Very high

517

(368–728)

1023

(600–1743)

346

(269–446)

638

(455–895)

2865

(1660–4945)

699

(609–803)

902

(788–1034)

801

(598–1074)

8 d

Negative

<10

<10

<10

<10

<10

<10

<10

<10

JEV Overall GMT

218

(152–313)

397

(271–584)

183

(138–244)

214

(154–300)

351

(201–613)

138

(89–214)

302

(218–418)

243

(209–282)

  1. GMTs are presented in bold font with 95% confidence intervals in parentheses.
  2. aResults from original study testing using JE-CV PRNT assay at Focus Diagnostics Ltd., US [22]; low = titer range 40–80, medium = titer range 160–320, high = titer range 640–2560, very high = titer range >5120., negative = <10.
  3. bRecent JEV isolate.
  4. cJEV isolate tested in previous clinical trials [5, 8].
  5. dSample 8 was not used in calculating overall (sample/JEV) GMT.