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Table 6 Positive predictive values of Crossing point (Cp) values with different cut-off limits for detection of severe sepsis/septic shock, for blood samples with a positive SeptiFast test for Gram-positive bacteria

From: Quantitative data from the SeptiFast real-time PCR is associated with disease severity in patients with sepsis

Cut-off Cp value Staphylococcus aureus(n = 24) Streptococcus species(n = 13) Gram-positive bacteria, other* (n = 5) Gram-positive bacteria total (n = 42)
<15.0 60% (3/5) 100% (1/1) 50% (1/2) 62% (5/8)
<17.5 62% (5/8) 71% (5/7) 67% (2/3) 67% (12/18)
<20.0 55% (6/11) 38% (5/13) 80% (4/5) 52% (15/29)
<22.5 33% (8/24)    41% (17/42)
  1. The Septifast method has a Cp cut-off at 20 cycles for test positivity for Streptococcus species, and at 25 cycles for other Gram-positive bacteria.
  2. Data is presented as percentages (No. of SeptiFast positive samples from patients with severe sepsis /No. of SeptiFast positive samples in total, according to cut-off).
  3. *Including: Enterococcus faecalis (n = 3) and Streptococcus pneumonia (n = 2).