Table 3 AUC _0-4h and normalized AUC _0-4h to RBV 600 mg/body weight

AUC_0-4h (μg.h/L)

2030 (851–7700)

1469 (936–3677)

0.018

Patients with AUC_0-4h <1755 (%)

32

61

0.014

Men AUC_0-4h (μg.h/L)

1875 (850–7700)

1414 (1034–3677)

0.050

Men with AUC_0-4h <1755 (%)

43

65

0.103

Normalized AUC_0-4h (μg.h/L)/(mg/kg)

271 (82–1091)

182 (110–425)

0.001

Men normalized AUC_0-4h (μg.h/L)/(mg/kg)

266 (82–1091)

173 (110–425)

0.004

CD4 < 500

CD4 ≥ 500

AUC_0-4h

1270 (936–2792)

1840 (1280–3677)

0.047

Normalized AUC_0-4h

144 (110–425)

195 (154–349)

0.108