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Table 3 AUC 0-4h and normalized AUC 0-4h to RBV 600 mg/body weight

From: Lower ribavirin biodisponibility in patients with HIV-HCV coinfection in comparison with HCV monoinfected patients

  HCV (n = 63) HIV-HCV (n = 23) p value
AUC0-4h (μg.h/L) 2030 (851–7700) 1469 (936–3677) 0.018
Patients with AUC0-4h <1755 (%) 32 61 0.014
Men AUC0-4h (μg.h/L) 1875 (850–7700) 1414 (1034–3677) 0.050
Men with AUC0-4h <1755 (%) 43 65 0.103
Normalized AUC0-4h (μg.h/L)/(mg/kg) 271 (82–1091) 182 (110–425) 0.001
Men normalized AUC0-4h (μg.h/L)/(mg/kg) 266 (82–1091) 173 (110–425) 0.004
   CD4 < 500 CD4 ≥ 500  
AUC0-4h   1270 (936–2792) 1840 (1280–3677) 0.047
Normalized AUC0-4h   144 (110–425) 195 (154–349) 0.108
  1. Quantitative variables are expressed as median and range. Bold style indicates statistical significance.