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Table 4 Cox proportional hazards analysis of factors associated with TB among people living with HIV/AIDS in the ClinSurv HIV Cohort, Germany 2001ā€“2011

From: Tuberculosis among people living with HIV/AIDS in the German ClinSurv HIV Cohort: long-term incidence and risk factors

Predictor variable

Patients never started cART*

Patients on cARTā€ 

Ā 

HR [95% CI]

Pvalue

HR [95% CI]

Pvalue

Gender

Ā Ā Ā Ā 

ā€ƒā€ƒā€‰Female

1

Ā 

1

Ā 

ā€ƒā€ƒā€‰Male

0.73 [0.36-1.47]

0.38 (NS)

1.49 [0.84- 2.62]

0.17 (NS)

Median age, years

Ā Ā Ā Ā 

ā€ƒā€ƒā€‰ā‰¤38

1

Ā 

1

Ā 

ā€ƒā€ƒā€‰>38

0.86 [0.47-1.58]

0.62 (NS)

1.42 0.89 2.27

0.14 (NS)

Region of origin

Ā Ā Ā Ā 

ā€ƒā€ƒā€‰Germany

1

Ā 

1

Ā 

ā€ƒā€ƒā€‰Sub-Saharan Africa

4.05 [1.87-8.78]

<0.001

5.15 [2.76-9.60]

<0.001

ā€ƒā€ƒā€‰Other countries

1.75 [0.81-38.1]

0.16

2.22 [1.18-4.20]

0.014

HIV-transmission risk group

Ā Ā Ā Ā 

ā€ƒā€ƒā€‰Othersā€ 

1

Ā 

1

Ā 

ā€ƒā€ƒā€‰MSM

0.68 [0.31-1.51]

0.34

0.60 [0.32-1.10]

0.10 (NS)

CD4+ cell count (cells/Ī¼l)

Ā Ā Ā Ā 

ā€ƒā€ƒā€‰ā‰„200

1

Ā 

1

Ā 

ā€ƒā€ƒā€‰<200

8.22 [4.36-15.51]

<0.001

1.90 [1.14-3.15]

0.013

Viral load (log10 copies/ml)

Ā Ā Ā Ā 

ā€ƒā€ƒā€‰< 5

1

Ā 

1

Ā 

ā€ƒā€ƒā€‰ā‰„ 5

2.51 [1.33-4.75]

0.005

1.77 [1.11-2.82]

0.016

  1. HR, hazard ratio; CI, confidence interval; NS, non-significant; MSM, men who have sex with men.
  2. *50Ā TB cases among 1,919 subjects. ā€ 78Ā TB cases among 6,357 subjects.
  3. ā€ Others included heterosexual, blood transfusion and mother to child transmission.