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Table 3 TB incidence density rate stratified by baseline demographic and clinical characteristics in the ClinSurv HIV Cohort, Germany 2001–2011

From: Tuberculosis among people living with HIV/AIDS in the German ClinSurv HIV Cohort: long-term incidence and risk factors

Characteristics No. of patients Person-years No. with TB TB IDR [95% CI] Pvalue*
Total patients 11,631 45,698 170 0.37 [0.32-0.43]  
Gender      0.04
   Female 2,283 9,153 45 0.49 [0.37-0.66]  
   Male 9,347 36,536 125 0.34 [0.29-0.41]  
Median age, years      0.41 (NS)
   ≤38 5,773 23,250 91 0.39 [0.32-0.48]  
   >38 5,838 22,387 78 0.35 [0.28-0.43]  
Region of origin      <0.001
   Germany 8,344 33,449 71 0.21 [0.17-0.27]  
   Sub-Sahara Africa 1,298 4,871 59 1.20 [0.94-1.56]  
   Other countries 1,789 6,710 34 0.52 [0.38-0.71]  
HIV-transmission risk group category      <0.001
   MSM 6,093 24,189 53 0.22 [0.17-0.28]  
   HPC 1,528 5,910 69 1.17 [0.92-1.48]  
   PWID 943 3,534 14 0.42 [0.23-0.67]  
   Others 1,846 7,768 22 0.28 [0.18-0.43]  
CD4+ blood cell count (cells/μl)      <0.001
   >350 5,037 19,702 44 0.22 [0.17-0.30]  
   200–350 2,459 9,893 37 0.36 [0.26-0.50]  
   <200 3,580 14,111 82 0.58 [0.47-0.72]  
Viral load (log10 copies/ml)      <0.001
   <5 7,583 30,137 92 0.31 [0.25-0.37]  
   ≥5 3,162 12,490 65 0.52 [0.41-0.66]  
Antiretroviral therapy      <0.001
   Never started cART 2,424 4,801 59 1.23 [0.95-1.59]  
   cART during follow-up 9,207 40,897 111 0.27 [0.23-0.33]  
Follow-up      <0.001
   First year 2,421 10,174 109 1.07 [0.89-1.29]  
   Second year 1,615 8,248 16 0.19 [0.12-0.32]  
  1. TB, tuberculosis; IDR, incidence density rate (cases per 100 person-years); CI, confidence interval; NS, non-significant; MSM, men who have sex with men; HPC, high HIV-prevalence countries; PWID, person who inject drugs; cART, combination antiretroviral therapy.
  2. *Obtained by χ2 test for difference in TB IDR.
  3. Others included heterosexual, blood transfusion and mother to child transmission.
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