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Table 2 Clinical manifestations, laboratory findings and outcomes among 35 cases of listeriosis

From: Emergence of sporadic non-clustered cases of hospital-associated listeriosis among immunocompromised adults in southern Taiwan from 1992 to 2013: effect of precipitating immunosuppressive agents

 

All ( n = 35)

Community-associated (n = 23)

Hospital-associated (n = 12)

p-value

Clinical findings

APACHE II score, median (range)

15 (4–46)

12 (4–46)

19 (6–30)

0.55

Headache (%)

4 (11.4)

3 (13)

1 (8.3)

1.0

Nausea (%)

3 (8.6)

1 (4.3)

2 (16.7)

0.27

Reduced consciousness (%)

11 (31.4)

6 (26.1)

5 (41.7)

0.45

Seizure (%)

6 (17.1)

3 (13)

3 (25)

0.39

Focal neurologic (%)

3 (8.6)

2 (8.7)

1 (8.3)

1.0

Diarrhea (%)

3 (8.6)

2 (8.7)

1 (8.3)

1.0

Fever (%)

31 (88.6)

20 (87)

11 (91.7)

1.0

Adequate antibiotic therapy within 24 hours (%)

4 (11.4)

1 (4.3)

3 (25)

0.16

CNS infection (%)

10 (28.6)

8 (34.8)

2 (16.7)

0.43

60-day mortality (%)

12 (34.3)

4 (17.4)

8 (66.7)

0.01

Hospital duration, median day (range)

28 (1–126)

20 (1–124)

53 (15–126)

0.01

Laboratory findings

ALT, median IU/L (range)

41 (6–248)

47.5 (6–248)

39 (15–177)

0.88

Total bilirubin, median mg/dL (range)

0.9 (0.2–7.9)

0.8 (0.2–4)

0.5 (0.2–7.9)

0.24

Albumin, median g/dL (range)

2.7 (1.4–3.9)

2.6 (1.7–3.8)

2.4 (1.4–3.9)

0.93

White blood cells, median 109/L (range)

8.38 (0.19–28.16)

13.39 (3.36–27.47)

8.38 (0.19–28.16)

0.06

Platelets, median /mm3 (range)

117 (4–350)

158.72 (27.7–350)

101.91 (4–275)

0.18

Serum creatinine, median mg/dL (range)

1.1 (0.4–17.2)

1.10 (0.58–17.2)

1.10 (0.4–8.84)

0.07

Site of L. monocytogenes isolates

    

Blood (%)

33 (94.3)

21 (91.3)

12 (100)

0.54

CSF (%)

6 (17.1)

5 (21.7)

1 (8.3)

0.64

Joint fluid (%)

1 (2.8)

1 (4.3)

0 (0)

1.0

  1. Data are no. (%) of patients, unless otherwise indicated. APACHE II, Acute Physiology And Chronic Health Evaluation II; ALT, alanine aminotransferase.