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Table 3 Persistence of hemagglutination-inhibition antibody geometric mean titers with 95% CI in the per-protocol immunogenicity cohort

From: Long-term booster schedules with AS03A-adjuvanted heterologous H5N1 vaccines induces rapid and broad immune responses in Asian adults

Month 6 6 + 21 days 12 12 + 21 days 18 24 30 36 36 + 21 days 42 48
Boosted at Month 6
Primary strain N = 256 N = 256 N = 228 N = 216 N = 200 N = 200 N = 208 N = 201 N = 194
  19.1 397.4 76.1   43.7 32.2 27.5 24.3   20.1 22.9
  (16.5, 22.5) (342.5, 461.0) (62.5, 92.7)   (36.7, 52.0) (27.3, 37.9) (23.6, 32.2) (20.6, 28.6)   (17.3, 23.5) (19.6, 26.9)
Booster strain N = 256 N = 256 N = 228 N = 216 N = 200 N = 200 N = 208 N = 201 N = 194
  6.4 321.3 46.9   4.9 22.2 22.1 24.5   17.8 19.5
  (6, 6.9) (274.3, 376.2) (38.3, 57.4)   (45.6, 66.1) (18.8, 26.0) (18.8, 26.0) (20.6, 29.1)   (15.2, 20.9) (16.6, 23.0)
Boosted at Month 12
Primary strain N = 665 N = 178 N = 184 N = 182 N = 177 N = 177 N = 178 N = 176 N = 170
  18.5   11.8 649.7 145.2 68.5 53.0 51.2   39.0 41.8
  (5, 5.1)   (10.0, 14.0) (549.6, 768.1) (118.1, 178.6) (55.9, 83.9) (44.6, 63.1) (42.3, 62.0)   (32.6, 46.6) (34.7, 50.4)
Booster strain N = 665 N = 178 N = 184 N = 182 N = 177 N = 177 N = 178 N = 176 N = 170
  6.3   6.2 338 190.7 51.3 45.5 52.4   37 37.9
  (6, 6.5)   (5.7, 6.7) (280, 407.2) (154.3, 235.7) (44.6, 63.1) (37.2, 55.8) (42.3, 65.1)   (30.3, 45.2) (30.9, 46.4)
Boosted at Month 36
Primary strain N = 365 N = 429 N = 411 N = 413 N = 387 N = 379 N = 378 N = 367
    11.3   10.2 10.8 10.7 10.5 653.1 225.4 165.1
    (10.1, 12.6)   (9.3, 11.3) (9.8, 11.8) (9.7, 11.7) (9.5, 11.6) (604.3–705.9) (205, 247.9) (149.8, 181.9)
Booster strain N = 364 N = 429 N = 411 N = 413 N = 387 N = 379 N = 378 N = 367
    6.2   9.6 6.0 6.3 7.0 877.5 263.5 171.3
    (5.8, 6.7)   (8.7, 10.6) (5.7, 6.3) (6.0, 6.6) (6.5, 7.6) (809.1, 951.6) (238.3, 291.3) (155.0, 189.3)
  1. CI, confidence interval; N, number of subjects in group; Responses are based on per-protocol immunogenicity cohort before vaccination and at vaccination + 21 days; responses at time-points post-vaccination are based on per-protocol immunogenicity persistence cohorts; Primary vaccine strain, H5N1/A/Vietnam/1194/2004; booster strain, H5N1/A/Indonesia/5/2005.