Community-onset bloodstream infection with multidrug-resistant organisms: a matched case-control study

BMC Infectious Diseases

Table 4 Predictors of 30-day all-cause mortality among patients with community-onset bloodstream infection

Variable	Patients who died in 30 days	Patients who survived	Univariate analysis		Multivariate analysis
	n = 46	n = 314	OR (95% CI)	P value	AOR (95% CI)	P value
Age, mean (SD), years	74.8 (16.3)	63.1 (19.9)	1.04 (1.02-1.06)	<0.001^a	1.04 (1.02-1.06)	<0.001
Male, no (%)	31 (67.4)	186 (59.2)	1.42 (0.74-2.74)	0.29
Residence in LTCF, no (%)	18 (39.1)	56 (17.8)	2.96 (1.53-5.72)	0.001^a
Charlson co-morbidity index, mean (SD)	3.5 (2.2)	2.6 (2.4)	1.15 (1.02-1.30)	0.018^a
Acquisition-healthcare associated, no (%)	35 (76.1)	185 (58.9)	2.22 (1.09-4.53)	0.029^a
Underlying immunosuppression, no (%)	14 (30.4)	98 (31.2)	0.96 (0.49-1.89)	0.92
High risk BSI sources^b, no (%)	30 (65.2)	153 (48.7)	1.97 (1.03-3.76)	0.039^a	2.30 (1.16-4.57)	0.02
Pitt bacteraemia score, median (IQR)	2 (1-4)	1 (0-2)	1.39 (1.18-1.64)	<0.001^a	1.36 (1.15-1.61)	<0.001
Severe sepsis or septic shock, no (%)	13 (28.3)	38(12.1)	2.86 (1.39-5.91)	0.005^c
ICU admission, no (%)	12 (26.1)	51 (16.2)	1.82 (0.88-3.75)	0.11
Bacteraemia due to MDR organisms, no (%)	28 (60.9)	152 (48.4)	1.66 (0.88-3.12)	0.12
Inactive empiric antibiotic, no (%)	16 (34.8)	61 (19.4)	2.21 (1.13-4.31)	0.02^a

NOTE. OR, odds ratio; AOR, adjusted odds ratio; CI, confidence interval; SD, standard deviation; IQR, interquartile range; LTCF, long-term care facility; BSI, bloodstream infections; ICU, intensive care unit; MDR, multidrug-resistant.
^aVariables eligible for inclusion in the multivariate analysis.
^bHigh risk sources refer to BSI secondary to respiratory, gastrointestinal, hepatobiliary, bone and joint, cardiovascular or unidentified sources.
^cPairwise correlation >0.7 with Pitt bacteraemia score.

ISSN: 1471-2334