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Table 3 Subgroup analyses of risk factors for community-onset bloodstream infection caused by MDR GNB and MRSA

From: Community-onset bloodstream infection with multidrug-resistant organisms: a matched case-control study

Variables

BSI with MDR GNB, case = 109, control = 109

BSI with MRSA, case = 67, control = 67

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

 

OR (95% CI)

P value

AOR (95% CI)

P value

OR (95% CI)

P value

AOR (95% CI)

P value

Age, years

0.99 (0.97-1.00)

0.045a

0.98 (0.96-1.00)

0.03

1.02 (1.00-1.04)

0.061a

  

Female

1.05 (0.58-1.91)

0.88

  

0.66 (0.31-1.41)

0.29

  

Low risk BSI sourcesb

1.29 (0.73-2.27)

0.39

  

1.71 (0.83-3.49)

0.15

  

Invasive device in-situ

3.43 (1.48-7.96)

0.004a

  

5.50 (1.90-15.96)

0.002a

  

  Indwelling catheter

2.60 (0.93-7.29)

0.07

  

11.00 (1.42-85.20)

0.02

  

  Vascular catheter

3.25 (1.06-9.97)

0.04

  

2.50 (0.78-7.97)

0.12

  

Friedman et al. HCA risk factors

4.90 (2.48-9.67)

<0.001

  

13.17 (4.07-42.59)

<0.001

  

  Prior hospitalisation (≥2d) last 90d

4.50 (2.27-8.93)

<0.001a

  

4.75 (2.31-9.75)

<0.001a

5.87 (1.37-25.21)

0.02

  Residence in long-term care facilities

2.44 (1.13-5.31)

0.024a

5.56 (1.60-19.34)

<0.01

3.78 (1.53-9.33)

0.004a

12.38 (2.45-62.63)

<0.01

  Home intravenous last 30d

8.00 (1.84-34.79)

0.006a

8.33 (1.52-45.75)

0.02

1.67 (0.61-4.59)

0.32

  

  Home wound care last 30d

1.67 (0.40-6.97)

0.48

  

13.94 (3.31-58.68)

<0.001a

6.74 (1.06-42.70)

0.04

  Haemodialysis last 30d

1.50 (0.25-8.98)

0.66

  

0.22 (0.05-1.03)

0.054a

  

  Intravenous chemotherapy last 30d

2.86 (1.29-6.43)

0.010a

  

1.75 (0.51-5.98)

0.37

  

Underlying immunosuppression

3.09 (1.57-6.10)

0.001a

  

6.67 (1.98-22.44)

0.002a

7.21 (1.20-43.43)

0.03

  Neutropenia

2.57 (1.07-6.16)

0.03

  

2.00 (0.37-10.92)

0.42

  

  Active or metastatic cancer

2.25 (1.14-4.44)

0.02

  

1.80 (0.60-5.37)

0.29

  

Surgery last 30d

6.50 (1.47-28.80)

0.014a

  

9.50 (2.21-40.79)

0.002a

  

Presence of BSI last 3mo

6.00 (1.77-20.37)

0.004a

  

6.50 (1.47-28.80)

0.014a

  

Prior antibiotic exposure last 3mo

8.29 (3.78-18.15)

<0.001a

7.94 (3.36-18.80)

<0.001

6.76 (2.87-15.92)

<0.001a

  

Diabetic

1.91 (0.92-3.96)

0.082a

  

1.75 (0.73-4.17)

0.21

  

Malignancy

1.81 (1.06-3.08)

0.029a

  

1.30 (0.57-2.97)

0.53

  

Charlson co-morbidity index

1.16 (1.04-1.30)

0.007a

  

1.38 (1.15-1.67)

0.001a

  

Intravenous drug user, IVDU

NA

NA

  

0.07 (0.01-0.51)

0.009a

  
  1. NOTE. OR, odds ratio; AOR, adjusted odds ratio; CI, confidence interval; BSI, bloodstream infections; HCA, healthcare-associated; NA, not applicable.
  2. aVariables eligible for inclusion in the multivariate analysis.
  3. bLow risk sites are BSI secondary to urinary, skin & soft tissue and catheter-related sites.
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BMC Infectious Diseases

ISSN: 1471-2334

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