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Table 3 Subgroup analyses of risk factors for community-onset bloodstream infection caused by MDR GNB and MRSA

From: Community-onset bloodstream infection with multidrug-resistant organisms: a matched case-control study

Variables BSI with MDR GNB, case = 109, control = 109 BSI with MRSA, case = 67, control = 67
Univariate analysis Multivariate analysis Univariate analysis Multivariate analysis
  OR (95% CI) P value AOR (95% CI) P value OR (95% CI) P value AOR (95% CI) P value
Age, years 0.99 (0.97-1.00) 0.045a 0.98 (0.96-1.00) 0.03 1.02 (1.00-1.04) 0.061a   
Female 1.05 (0.58-1.91) 0.88    0.66 (0.31-1.41) 0.29   
Low risk BSI sourcesb 1.29 (0.73-2.27) 0.39    1.71 (0.83-3.49) 0.15   
Invasive device in-situ 3.43 (1.48-7.96) 0.004a    5.50 (1.90-15.96) 0.002a   
  Indwelling catheter 2.60 (0.93-7.29) 0.07    11.00 (1.42-85.20) 0.02   
  Vascular catheter 3.25 (1.06-9.97) 0.04    2.50 (0.78-7.97) 0.12   
Friedman et al. HCA risk factors 4.90 (2.48-9.67) <0.001    13.17 (4.07-42.59) <0.001   
  Prior hospitalisation (≥2d) last 90d 4.50 (2.27-8.93) <0.001a    4.75 (2.31-9.75) <0.001a 5.87 (1.37-25.21) 0.02
  Residence in long-term care facilities 2.44 (1.13-5.31) 0.024a 5.56 (1.60-19.34) <0.01 3.78 (1.53-9.33) 0.004a 12.38 (2.45-62.63) <0.01
  Home intravenous last 30d 8.00 (1.84-34.79) 0.006a 8.33 (1.52-45.75) 0.02 1.67 (0.61-4.59) 0.32   
  Home wound care last 30d 1.67 (0.40-6.97) 0.48    13.94 (3.31-58.68) <0.001a 6.74 (1.06-42.70) 0.04
  Haemodialysis last 30d 1.50 (0.25-8.98) 0.66    0.22 (0.05-1.03) 0.054a   
  Intravenous chemotherapy last 30d 2.86 (1.29-6.43) 0.010a    1.75 (0.51-5.98) 0.37   
Underlying immunosuppression 3.09 (1.57-6.10) 0.001a    6.67 (1.98-22.44) 0.002a 7.21 (1.20-43.43) 0.03
  Neutropenia 2.57 (1.07-6.16) 0.03    2.00 (0.37-10.92) 0.42   
  Active or metastatic cancer 2.25 (1.14-4.44) 0.02    1.80 (0.60-5.37) 0.29   
Surgery last 30d 6.50 (1.47-28.80) 0.014a    9.50 (2.21-40.79) 0.002a   
Presence of BSI last 3mo 6.00 (1.77-20.37) 0.004a    6.50 (1.47-28.80) 0.014a   
Prior antibiotic exposure last 3mo 8.29 (3.78-18.15) <0.001a 7.94 (3.36-18.80) <0.001 6.76 (2.87-15.92) <0.001a   
Diabetic 1.91 (0.92-3.96) 0.082a    1.75 (0.73-4.17) 0.21   
Malignancy 1.81 (1.06-3.08) 0.029a    1.30 (0.57-2.97) 0.53   
Charlson co-morbidity index 1.16 (1.04-1.30) 0.007a    1.38 (1.15-1.67) 0.001a   
Intravenous drug user, IVDU NA NA    0.07 (0.01-0.51) 0.009a   
  1. NOTE. OR, odds ratio; AOR, adjusted odds ratio; CI, confidence interval; BSI, bloodstream infections; HCA, healthcare-associated; NA, not applicable.
  2. aVariables eligible for inclusion in the multivariate analysis.
  3. bLow risk sites are BSI secondary to urinary, skin & soft tissue and catheter-related sites.