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Table 3 Choice of empirical antimicrobial regimen according to suspected and confirmed focus of infection and compliance with recommendations (n/n (%))

From: Aetiology, antimicrobial therapy and outcome of patients with community acquired severe sepsis: a prospective study in a Norwegian university hospital

Focus of infection with recommended regimen Suspected focus at admission Total cases/Cases with correct regimena Confirmed focus at discharge Total cases/Cases with appropriate regimena
Respiratory b,c 100d/82 (82.0) 115d/96 (83.5)
penicillin G and ciprofloxacin or
penicillin G and gentamicin e,f
Genitourinary 25d/20 (80.0) 30d/24 (80.0)
ampicillin and gentamicin f
Soft tissue 23/18 (78.3) 27d/18 (66.7)
penicillin G and clindamycin (+/- gentamicin)
Abdominal 16d/11 (68.8) 26d/13 (50.0)
ampicillin and gentamicin and metronidazol or
3rd generation cephalosporin and metronidazol or
piperacillin-tazobactam or
meropenem
Endocarditis 4/3 (75.0) 12/7 (58.3)
penicillin G and gentamicin or
3rd generation cephalosporin
CNS 4/3 (75.0) 4/4 (100)
penicillin G and 3rd generation cephalosporin
Unknown/bacteremia 38d/34 (89.5) 5/5 (100)
penicillin G and gentamicin (+/- metronidazol)e,f
Total 210/171 (81.4) 219/167 (76.3)
  1. aCorrect and appropriate regimen according to recommendations for empirical antimicrobial therapy in Haukeland University Hospital in 2008.
  2. bOne patient with a suspected and later verified respiratory tract infection died before antimicrobial therapy was implemented.
  3. cSuspected atypical pneumonia: macrolide or doxycycline is added.
  4. dNumber of correct cases including one patient given meropenem as initial agent (n = 4 in total).
  5. eIf allergic to penicillin: clindamycin.
  6. fIf gentamicin is contraindicated: 3rd generation cephalosporin monotherapy.