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Figure 2 | BMC Infectious Diseases

Figure 2

From: CD4 T cell activation by B cells in human Leishmania (Viannia)infection

Figure 2

Stimulation with pLAg induces upregulation of costimulatory molecules in APCs from CL patients. PBMCs were isolated from peripheral blood of CL patients (CLP, n = 10) and healthy subjects (HS, n = 4), incubated with promastigote L. panamensis antigen (pLAg) for 5 days and stained for CD20, CD11c, CD86, CD80 and HLA-DR. A. Histograms of cells within the CD20+ lymphocyte gate (B cells, top panels) and CD11chiFShi gate (DCs, bottom panels) from representative HS and CLP showing the effects of pLAg on expression of CD86, CD80 and HLA-DR. B. Percentages of variation in mean fluorescence intensity (MFI) of each marker in cells incubated with pLAg in relation to controls for HS and CLP. **p < 0.01, ***p < 0.001.

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