Table 2 Determinants of CHC treatment decision in CHC patients >3 months on OMT
Determinants | Treatment start (n=35) | No CHC treatment (n=50) | P-value* |
|---|---|---|---|
% (n) or median [IQR] | % (n) or median [IQR] | ||
Demographics: | |||
Male | 65.7 [23] | 58 [29] | |
Female | 34.3 [12] | 42 [21] | 0.48 |
Age (years) | 41.8 (37.2-45.1) | 37.5 (34.8-43.8) | 0.06 |
Age beginning OMT (years) | 35.0 (31.9-39.9) | 33.4 (29.2-39.1) | 0.45 |
Opiate maintenance therapy: | |||
Methadone | 88.5 (31) | 92 (46) | |
Buprenorphin | 8.6 [3] | 2 [1] | |
Morphin | 2.9 [1] | 6 [3] | 0.51 |
Single OMT therapy | 88.6 (31) | 86 (43) | |
Use of ≥1 different opiate in the past | 11.4 [4] | 14 [7] | 1.0 |
Duration of OMT (months) | 55.0 (35.0-110.1) | 24.0 (9.8-46.3) | <0.001# |
Average methadone dose during OMT (mg) | 73 (50–120) | 73 (50–122) | 0.83 |
Psychiatric comorbidity: | |||
None or stable disorder | 68.6 [24] | 52 [24] | |
Unstable disorder | 31.4 [11] | 48 [26] | 0.060 |
Injection drug use (IDU): | |||
In the past, yes | 91 (32) | 94 (47) | |
In the past, no | 9 [3] | 6 [3] | 0.69 |
Current, yes | 8.6 [3] | 24 [12] | |
Current, no | 91.4 (32) | 76 (38) | 0.086 |
Other drug and excessive alcohol use: | |||
Current heroin use | 20 [7] | 32 [16] | |
No heroin use | 80 [28] | 68 (34) | 0.22 |
Current cocaine use | 25.7 [9] | 26 [13] | |
No cocaine use | 74.3 [26] | 74 (37) | 0.98 |
Current benzodiazepine use | 14.7 [5] | 26 [12] | |
No benzodiazepine use | 85.3 [29] | 74 (38) | 0.41 |
Excessive alcohol use | 28.6 [10] | 34 [17] | |
No alcohol excess | 71.4 [25] | 66 (33) | 0.60 |
Occupational and housing variables: | |||
Employability (%) | 60 (30–100) | 60 (30–100) | 0.52 |
Single household | 40 [14] | 34 [17] | |
Shared household | 51.4 [18] | 56 [28] | |
Other lodging | 8.6 [3] | 10 [5] | 0.90 |
HIV-co-infection† | |||
HIV positive | 14.7 [5] | 23.9 [11] | |
HIV negative | 85.3 [29] | 76.1 (35) | 0.40 |