Table 1 Summary of risk factors associated with carbapenem-resistant K. pneumoniae infection
Risk factor | Case patients (n = 20) | Control patients (n = 40) | Univariable analysis | Multivariable analysis | ||
|---|---|---|---|---|---|---|
OR (95% CI) | p | OR (95% CI) | p | |||
Male sex | 13 (65.0) | 21 (52.5) | 0.59 (0.19-1.81) | 0.36 | ||
Mean Age (years) | 59.6 | 64.9 | 5.35 (−6.89-17.59) | 0.38 | ||
McCabe score | ||||||
Rapidly fatal | 4 (20.0) | 11 (27.5) | 1.52 (0.42-5.55) | 0.75 | ||
Potentially fatal/Non-fatal | 16 (80.0) | 29 (72.5) | ||||
Charlson score ≥ 3 | 11 (55.0) | 12 (30.0) | 2.85 (0.94-8.66) | 0.06 | ||
Transplant receipt | 7 (35.0) | 6 (15.0) | 0.33 (0.09-1.16) | 0.10 | ||
Prior corticosteroid use | 16 (80.0) | 22 (55.0) | 0.31 (0.09-1.08) | 0.06 | ||
Prior surgery | 14 (70.0) | 22 (55.0) | 0.53 (0.17-1.64) | 0.27 | ||
Dialysis | 6 (30.0) | 6 (15.0) | 0.42 (0.12-1.49) | 0.17 | ||
ICU stay* | 20 (100) | 32 (80.0) | 0.62 (0.49-0.76) | 0.03 | - | - |
Mean APACHE II score at admission | 22.1 | 16.4 | 1.10 (1.02-1.19) | 0.02 | 1.10 (0.97-1.25) | 0.13 |
Mean SOFA score at admission | 7.35 | 5.63 | 1.14 (0.98-1.32) | 0.09 | ||
Mean length of stay before infection (days) | 45.5 | 27 | 0.11 | |||
Device use | ||||||
CVC | 17 (85.0) | 23 (57.5) | 4.18 (1.10-16.7) | 0.04 | 0.05 (0.01-2.20) | 0.12 |
Mechanical ventilation | 4 (20.0) | 5 (12.5) | 0.57 (0.13-2.42) | 0.46 | ||
Urinary catheter | 12 (60.0) | 29 (72.5) | 1.56 (0.51-4.77) | 0.44 | ||
Mean device use (days) | ||||||
CVC | ||||||
Urinary catheter | 23.5 | 12.2 | 0.02 | 1.07 (0.99-1.16) | 0.07 | |
Mechanical ventilation | 13.0 | 17.1 | 0.56 | |||
21.0 | 22.0 | 0.98 | ||||
Prior antimicrobial use** | 20 (100) | 31 (77.5) | 1.67 (1.32-2.05) | 0.02 | - | 1.0 |