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Table 1 Gyr A mutation and the susceptibilities to levofloxacin and ciprofloxacin in 327 isolates of Enterobacteriaceae

From: Specific patterns of gyr A mutations determine the resistance difference to ciprofloxacin and levofloxacin in Klebsiella pneumoniae and Escherichia coli

Mutation

No. of isolatesa

CLSI levofloxacin MIC breakpoint

P value

ORd(CIe-95%)

CLSI ciprofloxacin MIC breakpoint

P value

OR (CI-95%)

≥8 μg/mlb

<8 μg/ml

≥4 μg/ml

<4 μg/mlc

No mutation

66 (29)

4 (0)

43 (29)

  

5 (0)

61(29)

  

Mutation

261(154)

210(136)

51(18)

<0.001

45.365(15.562-132.246)

232(143)

29(11)

<0.001

97.600 (36.262-262.690)

Ser83Tyr

10 (9)

2 (1)

8 (8)

<0.05

2.688(0.419-17.222)

6 (5)

4 (4)

<0.001

18.300(3.848-87.038)

Ser83Ile

10 (1)

8(1)

2 (0)

<0.001

43.000 (6.710-275.554)

9 (1)

1 (0)

<0.001

109.8 (11.478-1050.351)

Ser83Leu+Asp87Asn

169 (96)

152 (96)

17 (0)

<0.001

96.118 (30.722-300.715)

163 (96)

6 (0)

<0.001

331.433 (97.582-1125.700)

Ser83Leu+Asp87Tyr

38 (34)

37(33)

1 (1)

<0.001

397.750(42.558-3717.362)

37 (33)

1(1)

<0.001

451.400(50.745-4015.373)

Ser83Phe+Asp87Asn

4(4)

3(3)

1(1)

<0.001

32.250(2.689-386.757)

4(4)

0

<0.001

0

Ser83Phe

7 (6)

1(0)

6 (6)

>0.05

1.792(0.171-18.822)

3 (2)

4 (4)

<0.05

9.15(1.586-52.799)

Ser83Leu

14(1)

4(0)

10 (1)

>0.05

4.300(0.915-20.205)

5 (0)

9 (1)

<0.05

6.778(1.633-28.139)

Asp87Asn

1 (0)

0

1 (0)

-

-

1 (0)

0

-

-

Ser83Thr

3 (0)

0

3 (0)

-

-

0

3 (0)

-

-

Ser83Ala

1(1)

0

1(1)

-

-

0

1(1)

-

 

Ser83Phe+Asp87Tyr

1(1)

0

1(1)

-

-

1(1)

0

-

-

Ser83Tyr+Asp87Tyr

1 (1)

1 (1)

0

-

-

1 (1)

0

-

-

Ser83Leu+Asp87His

1(0)

1(0)

0

-

-

1(0)

0

-

-

Ser83Phe+Asp87Ala

1(0)

1(0)

0

-

-

1(0)

0

-

-

Total

327(183)

214 (135)

113 (48)

  

237 (143)

90 (40)

  
  1. a: Numbers in brackets are isolates number in reference.
  2. b: CLSI breakpoint for levofloxacin resistance.
  3. c: CLSI breakpoint for ciprofloxacin resistant.
  4. -: limited numbers of isolates, no statistical analysis could be done.
  5. d: OR: odd ratio.
  6. e: CI: Confidence Interval.