Mutation | No. of isolatesa | CLSI levofloxacin MIC breakpoint | P value | ORd(CIe-95%) | CLSI ciprofloxacin MIC breakpoint | P value | OR (CI-95%) | ||
---|---|---|---|---|---|---|---|---|---|
≥8 μg/mlb | <8 μg/ml | ≥4 μg/ml | <4 μg/mlc | ||||||
No mutation | 66 (29) | 4 (0) | 43 (29) | Â | Â | 5 (0) | 61(29) | Â | Â |
Mutation | 261(154) | 210(136) | 51(18) | <0.001 | 45.365(15.562-132.246) | 232(143) | 29(11) | <0.001 | 97.600 (36.262-262.690) |
Ser83Tyr | 10 (9) | 2 (1) | 8 (8) | <0.05 | 2.688(0.419-17.222) | 6 (5) | 4 (4) | <0.001 | 18.300(3.848-87.038) |
Ser83Ile | 10 (1) | 8(1) | 2 (0) | <0.001 | 43.000 (6.710-275.554) | 9 (1) | 1 (0) | <0.001 | 109.8 (11.478-1050.351) |
Ser83Leu+Asp87Asn | 169 (96) | 152 (96) | 17 (0) | <0.001 | 96.118 (30.722-300.715) | 163 (96) | 6 (0) | <0.001 | 331.433 (97.582-1125.700) |
Ser83Leu+Asp87Tyr | 38 (34) | 37(33) | 1 (1) | <0.001 | 397.750(42.558-3717.362) | 37 (33) | 1(1) | <0.001 | 451.400(50.745-4015.373) |
Ser83Phe+Asp87Asn | 4(4) | 3(3) | 1(1) | <0.001 | 32.250(2.689-386.757) | 4(4) | 0 | <0.001 | 0 |
Ser83Phe | 7 (6) | 1(0) | 6 (6) | >0.05 | 1.792(0.171-18.822) | 3 (2) | 4 (4) | <0.05 | 9.15(1.586-52.799) |
Ser83Leu | 14(1) | 4(0) | 10 (1) | >0.05 | 4.300(0.915-20.205) | 5 (0) | 9 (1) | <0.05 | 6.778(1.633-28.139) |
Asp87Asn | 1 (0) | 0 | 1 (0) | - | - | 1 (0) | 0 | - | - |
Ser83Thr | 3 (0) | 0 | 3 (0) | - | - | 0 | 3 (0) | - | - |
Ser83Ala | 1(1) | 0 | 1(1) | - | - | 0 | 1(1) | - | Â |
Ser83Phe+Asp87Tyr | 1(1) | 0 | 1(1) | - | - | 1(1) | 0 | - | - |
Ser83Tyr+Asp87Tyr | 1 (1) | 1 (1) | 0 | - | - | 1 (1) | 0 | - | - |
Ser83Leu+Asp87His | 1(0) | 1(0) | 0 | - | - | 1(0) | 0 | - | - |
Ser83Phe+Asp87Ala | 1(0) | 1(0) | 0 | - | - | 1(0) | 0 | - | - |
Total | 327(183) | 214 (135) | 113 (48) | Â | Â | 237 (143) | 90 (40) | Â | Â |