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Table 3 MDR serotype 19A isolates from IPD in German children, before and after introduction of pneumococcal conjugate vaccine

From: Epidemiology of serotype 19A isolates from invasive pneumococcal disease in German children

Date of Isolation Diagnosis Source CC ST PEN* (μg/ml) CLA* (μg/ml) CLI* (μg/ml) TET* (μg/ml)
Pre-vaccination
01.03.1999   CSF 230 230 0.25 32 32 32
09.09.1999   Blood 473 3344 0.03 32 32 32
27.01.2000   Blood 3111 6968 0.015 4 2 32
28.11.2000   Blood 63 1621 0.015 4 2 16
31.12.2001   Blood 230 230 0.12 32 32 16
01.01.2003   Blood n.d. n.d. 0.015 32 32 2
04.01.2005   Swab mastoid 230 230 0.25 32 32 32
07.01.2005   Blood 177 193 0.015 32 32 32
23.11.2005 Sepsis Blood 15 3546 0.015 32 32 32
Post-vaccination
29.09.2006 others Blood 432 1848 0.015 16 16 16
25.11.2006 Otitis media Blood 199 416 0.015 16 16 16
21.12.2006 Pneumonia Blood 230 276 2 16 16 16
08.01.2007 Meningitis CSF 177 193 0.015 16 16 16
08.06.2007 Pneumonia Pleuraempyema 177 193 0.015 16 16 16
20.10.2007 Sepsis Blood 177 193 0.015 16 16 16
05.11.2008 Pneumonia Blood 320 320 4 16 16 16
29.03.2009 Sepsis Blood 320 320 4 16 16 16
20.04.2009 Pleuritis Drainage thorax 320 2432 4 16 16 16
10.05.2009   Blood 81 81 2 8 0.5 16
29.06.2009   Blood 230 319 0.25 16 16 16
06.10.2009 Mastoiditis Swab mastoid 230 319 0.5 16 16 16
07.11.2009 Sepsis Blood 199 416 0.015 16 16 16
11.12.2009 Sepsis Blood 320 320 2 16 16 0.25
15.01.2010 Pneumonia Pleural fluid 320 320 2 16 16 16
23.02.2010   Blood 63 63 0.25 16 16 16
03.04.2010 Pneumonia Blood 432 1848 0.015 16 16 4
05.05.2010 Sepsis Blood 320 320 4 16 16 16
08.07.2010 Otitis media Blood 15 15 0.5 16 16 0.5
20.07.2010   CSF 63 63 0.12 16 16 16
16.09.2010 Phlegmon Blood 230 319 0.5 16 16 0.5
26.09.2010 Pneumonia Blood 230 276 2 16 4 16
28.12.2010   Blood 199 416 0.015 16 16 16
30.03.2011   Blood 63 63 0.06 16 16 16
13.04.2011 Meningitis CSF 177 3863 0.015 16 16 16
30.06.2011 Meningitis CSF 230 319 1 16 16 0.5
  1. *PEN, penicillin; CLA, clarithromycin; CLI, clindamycin; TET, tetracycline.