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Table 3 Associations between vitamin D status and bone and inflammation biomarkers (univariate analysis)

From: Severe hypovitaminosis D correlates with increased inflammatory markers in HIV infected patients

  

All patients

Severe 25-(OH) vitamin D3 deficiency (<10ng/ml)

moderate 25-(OH) vitamin D3 deficiency (10–30 ng/ml)

25-(OH) Vitamin D3 >30 ng/ml

p value

  

N = 263

N = 95 (36%)

N = 135 (51%)

N = 33 (13%)

 

Bone metabolism parameters

Ionized calcium <1.12 mmols/l, n (%)

9 (3%)

3 (3%)

3 (2%)

3 (9%)

0.001

 

CTX (ng/mL), median (interquartile range)

0.45 (0.30-0.77)

0.49 (0.31-0.92)

0.45 (0.31-0.70)

0.33 (0.22-0.60)

0.05

 

High serum CTX, n (%)

56 (21%)

29 (32%)

24 (18%)

3 (9%)

0.01

 

Serum intact parathyroid hormone > 65 ng/l, n (%)

62 (24%)

31 (34%)

29 (21%)

2 (6%)

<0.0001

inflammation parameters

hsCRP (mg/l), median (interquartile range)

1.7 (0.7-4.0)

2.3 (1.2-5.3)

1.5 (0.9-2.7)

1.4 (0.8-4.2)

0.12

 

IL6 (pg/ml), median (interquartile range)

1.8 (1.0-3.6)

2.0 (0.7-6.3)

1.7 (0.6-3.6)

1.6 (1.0-3.8)

0.002

  1. hsCRP: highly-sensitive C-Reactive Protein; IL6: Interleukin 6; High serum CTX = C Telopeptide X > 0.748 ng/ml (men), 0.738 ng/ml (pre-menopausal women), and 1.351 ng/ml (menopausal women).