From: Severe hypovitaminosis D correlates with increased inflammatory markers in HIV infected patients
 |  | All patients | Severe 25-(OH) vitamin D3 deficiency (<10ng/ml) | moderate 25-(OH) vitamin D3 deficiency (10–30 ng/ml) | 25-(OH) Vitamin D3 >30 ng/ml | p value |
---|---|---|---|---|---|---|
 |  | N = 263 | N = 95 (36%) | N = 135 (51%) | N = 33 (13%) |  |
Bone metabolism parameters | Ionized calcium <1.12 mmols/l, n (%) | 9 (3%) | 3 (3%) | 3 (2%) | 3 (9%) | 0.001 |
 | CTX (ng/mL), median (interquartile range) | 0.45 (0.30-0.77) | 0.49 (0.31-0.92) | 0.45 (0.31-0.70) | 0.33 (0.22-0.60) | 0.05 |
 | High serum CTX, n (%) | 56 (21%) | 29 (32%) | 24 (18%) | 3 (9%) | 0.01 |
 | Serum intact parathyroid hormone > 65 ng/l, n (%) | 62 (24%) | 31 (34%) | 29 (21%) | 2 (6%) | <0.0001 |
inflammation parameters | hsCRP (mg/l), median (interquartile range) | 1.7 (0.7-4.0) | 2.3 (1.2-5.3) | 1.5 (0.9-2.7) | 1.4 (0.8-4.2) | 0.12 |
 | IL6 (pg/ml), median (interquartile range) | 1.8 (1.0-3.6) | 2.0 (0.7-6.3) | 1.7 (0.6-3.6) | 1.6 (1.0-3.8) | 0.002 |