|
Characteristica
|
Daptomycin dose (mg/kg)
| |
|---|
|
≤ 8 (n = 41)
|
> 8 (n = 26)
|
P value
|
|---|
|
Age, years
|
56 (18–89)
|
58.5 (22–87)
|
0.57
|
|
Male (%)
|
23 (56.1%)
|
17 (65.4%)
|
0.45
|
|
Weight, kg
|
56 (37–89)
|
61.5 (42–87)
|
0.13
|
|
Creatinine clearance, mL/min
|
38 (5–263)
|
57.5 (10–210)
|
0.54
|
|
Indwelling catheter useb
|
31 (75.6%)
|
16 (61.5%)
|
0.22
|
|
Surgery within 3 months
|
13 (31.7%)
|
10 (38.5%)
|
0.57
|
|
Underlying diseases
| | | |
|
Diabetes mellitus
|
14 (34.1%)
|
8 (30.8%)
|
0.77
|
|
Cirrhosis of liver
|
1 (2.4%)
|
4 (15.4%)
|
0.14
|
|
ESRD
|
11 (26.8%)
|
7 (26.9%)
|
0.99
|
|
Heart failure
|
11 (26.8%)
|
11 (42.3%)
|
0.19
|
|
Chronic lung disease
|
5 (12.2%)
|
3 (11.5%)
|
0.94
|
|
Malignancy
|
17 (41.5%)
|
6 (23.1%)
|
0.12
|
|
Charlson index
|
4 (0–11)
|
3.5 (0–11)
|
0.46
|
|
Pitt bacteremia scorec
|
4 (0–10)
|
3 (0–7)
|
0.85
|
|
ICU stay
|
24 (58.5%)
|
17 (65.4%)
|
0.58
|
|
SOFA scored
|
7 (2–17)
|
8 (0–17)
|
0.49
|
|
Ventilator use
|
19 (46.3%)
|
14 (53.8%)
|
0.55
|
|
Previous anti-gram positive antibiotic
| | | |
|
Vancomycin
|
28 (68.3%)
|
22 (84.6%)
|
0.14
|
|
Teicoplanin
|
13 (31.7%)
|
9 (34.6%)
|
0.81
|
|
Linezolid
|
5 (12.2%)
|
4 (15.4%)
|
0.71
|
-
a Data are median (range) for continuous variables.
-
b Including central venous catheter, port-A catheter, Hickman catheter, temporal pacemaker, and intra-aortic balloon pump.
-
c Only for bacteremic patients.
-
d Only for ICU patients.
-
ESRD, end-stage renal disease; ICU, intensive care unit; SOFA, Sequential Organ Failure Assessment; VHD, valvular heart disease.
