From: Analysis of HCV quasispecies dynamic under selective pressure of combined therapy
Patient and type of treatment responsea | Sex | Age | HCV Genotype | Sample | Viral Load log UI/ml | Genetic Distance | Genetic Distance from baselineb | Shannon Entropy |
---|---|---|---|---|---|---|---|---|
SVR | ||||||||
P05 | F | 44 | 1b | ● | 6.04 | 0.006 ± 0.001 | 0.0096 | |
P35 | M | 40 | 1a | ● | 6.25 | 0.005 ± 0.001 | 0.0074 | |
P40 | M | 35 | 1a | ● | 6.57 | 0.004 ± 0.001 | 0.0042 | |
NR | ||||||||
P08 | F | 41 | 1a | ● | 5.80 | 0.008 ± 0.001 | 0.0126 | |
12wt | 4.59 | 0.009 ± 0.001 | 0.009 ± 0.001 | 0.0113 | ||||
14d | 6.18 | 0.011 ± 0.001 | 0.014 ± 0.002 | 0.0157 | ||||
2m | 6.46 | 0.008 ± 0.001 | 0.014 ± 0.002 | 0.0103 | ||||
6m | 6.40 | 0.007 ± 0.001 | 0.015 ± 0.002 | 0.0156 | ||||
P11 | M | 72 | 1b | ● | 6.85 | 0.017 ± 0.001 | 0.0235 | |
12wt | 3.71 | 0.007 ± 0.001 | 0.020 ± 0.003 | 0.0140 | ||||
14d | 6.27 | 0.005 ± 0.001 | 0.032 ± 0.004 | 0.0134 | ||||
2m | 6.73 | 0.007 ± 0.001 | 0.034 ± 0.004 | 0.0132 | ||||
6m | >7.2 | 0.012 ± 0.002 | 0.030 ± 0.004 | 0.0192 | ||||
P146 | M | 21 | 1a | ● | 6.92 | 0.012 ± 0.002 | 0.0202 | |
12wt | 5.54 | 0.006 ± 0.001 | 0.014 ± 0.002 | 0.0097 | ||||
14d | 6.43 | 0.012 ± 0.001 | 0.020 ± 0.002 | 0.0172 | ||||
2m | 6.76 | 0.012 ± 0.001 | 0.020 ± 0.002 | 0.0177 | ||||
6m | 6.96 | 0.008 ± 0.001 | 0.017 ± 0.002 | 0.0119 | ||||
P44 | M | 51 | 1b | ● | 6.50 | 0.016 ± 0.002 | 0.0139 | |
12wt | 6.13 | 0.019 ± 0.002 | 0.019 ± 0.002 | 0.0311 | ||||
14d | 6.24 | 0.014 ± 0.001 | 0.023 ± 0.003 | 0.0206 | ||||
2m | 7.18 | 0.014 ± 0.001 | 0.023 ± 0.003 | 0.0216 | ||||
6m | 6.83 | 0.014 ± 0.001 | 0.024 ± 0.003 | 0.0216 | ||||
ETR | ||||||||
P03 | M | 39 | 1a | ● | 5.95 | 0.011 ± 0.001 | 0.0131 | |
28d | 4.99 | 0.004 ± 0.001 | 0.041 ± 0.005 | 0.0094 | ||||
2m | 5.39 | 0.003 ± 0.001 | 0.039 ± 0.005 | 0.0058 | ||||
3m | 4.74 | 0.003 ± 0.001 | 0.039 ± 0.005 | 0.0055 | ||||
4m | 5.03 | 0.002 ± 0.001 | 0.039 ± 0.005 | 0.0073 | ||||
5m | 5.26 | 0.001 ± 0.001 | 0.038 ± 0.005 | 0.0033 | ||||
6m | 5.08 | 0.012 ± 0.000 | 0.038 ± 0.005 | 0.0038 | ||||
P37 | M | 27 | 1a | ● | 6.00 | 0.005 ± 0.001 | 0.0137 | |
2m | 6.63 | 0.001 ± 0.001 | 0.017 ± 0.003 | 0.0055 | ||||
3m | 6.83 | 0.002 ± 0.001 | 0.016 ± 0.003 | 0.0038 | ||||
4m | 6.30 | 0.003 ± 0.001 | 0.016 ± 0.003 | 0.0066 | ||||
5m | 6.10 | 0.009 ± 0.001 | 0.017 ± 0.003 | 0.0074 | ||||
6m | 6.58 | 0.014 ± 0.001 | 0.019 ± 0.003 | 0.0109 | ||||
P42 | M | 56 | 1b | ● | 6.66 | 0.016 ± 0.002 | 0.0161 | |
4m | 6.24 | 0.014 ± 0.002 | 0.030 ± 0.003 | 0.0162 | ||||
5m | 6.28 | 0.017 ± 0.002 | 0.028 ± 0.003 | 0.0141 | ||||
6m | 6.34 | 0.022 ± 0.002 | 0.030 ± 0.003 | 0.0145 | ||||
P47 | M | 47 | 1a | ● | 6.05 | 0.033 ± 0.002 | 0.0268 | |
2m | 5.67 | 0.027 ± 0.003 | 0.039 ± 0.004 | 0.0466 | ||||
3m | 5.92 | 0.003 ± 0.002 | 0.039 ± 0.004 | 0.0391 | ||||
4m | 5.57 | 0.011 ± 0.001 | 0.037 ± 0.004 | 0.0072 | ||||
5m | 5.87 | 0.009 ± 0.002 | 0.038 ± 0.004 | 0.0197 | ||||
6m | 2.93 | 0.011 ± 0.002 | 0.041 ± 0.004 | 0.0171 |