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Table 4 Incidence of first serious morbidity event, death, loss to follow-up and attrition following ART initiation, by pre-ART CD4 strata;, CMSDS, Abidjan, Côte d’Ivoire, 2003-2008

From: Incidence of serious morbidity in HIV-infected adults on antiretroviral therapy in a West African care centre, 2003-2008

  CD4 count at ART initiation (cell/mm3) P **
  < 100 100 to 200 > 200  
Serious morbidity        
Overall        10-2
    Events, n (Time at risk/100 PY) 58 (348) 49 (474) 85 (850)  
    Incidence/100 PY (95% CI) 16.7 (12.4-20.9) 10.4 (7.5-13.3) 10.0 (7.9-12.1)  
WHO stage III or IV events        0.40
    Events number (Time at risk/100 PY) 13 (391) 15 (549) 21 (1009)  
    Incidence/100 PY (95% CI) 3.1 (1.3-4.8) 2.7 (1.4-4.1) 2.1 (1.2-3.0)  
ANRS grade 3 or 4        0.60
    Events number (Time at risk/100 PY) 11 (392) 10 (558) 24 (1022)  
    Incidence/100 PY (95% CI) 2.8 (1.2-4.5) 1.8 (0.7-2.9) 2.4 (1.4-3.3)  
Confirmed malaria        2.10-2
    Events number (Time at risk/100 PY) 6 (381) 15 (529) 42 (968)  
    Incidence/100 PY (95% CI) 1.6 (0.3-2.8) 2.8 (1.4-4.3) 4.3 (3.0-5.7)  
Other events*        7.10-2
    Events number (Time at risk/100 PY) 13 (387) 9 (562) 15 (1060)  
    Incidence/100 PY (95% CI) 3.4 (1.5-5.2) 1.6 (0.6-2.7) 1.4 (0.7-2.1)  
Death        10-4
    Events number (Time at risk/100 PY) 26 (399) 13 (575) 8 (1100)  
    Incidence/100 PY (95% CI) 6.5 (4.0-9.0) 2.3 (1.0-3.5) 0.7 (0.2-1.2)  
Lost to follow-up        10-4
    Events number (Time at risk/100 PY) 40 (415) 47 (596) 41 (1138)  
    Incidence/100 PY (95% CI) 9.6 (6.7-12.6) 7.9 (5.6-10.1) 3.6 (2.5-4.7)  
Attrition        10-4
    Events number (Time at risk/100 PY) 66 (412) 70 (592) 49 (1132)  
    Incidence/100 PY (95% CI) 16.0 (12.1-19.9) 11.8 (9.1-14.6) 4.3 (3.1-5.5)  
  1. PY, Person-Years; CI, Confidence Interval; ART, Antiretroviral Therapy; WHO, World Health Organization; ANRS, Agence Nationale de Recherche sur le SIDA et les Hépatites Virales.
  2. *: non-classifying events with ≥ one day at hospital, or leading to death.
  3. Lost to follow-up: patients whose last contact with the study center was prior to 31 Dec 2008, and who were not found to be deceased, alive, or transferred out up to August 31st 2009.
  4. **: univariable Poisson models.