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Table 2 Details of the 278 serious morbidity events recorded after ART initiation, CMSDS, Abidjan, Côte d’Ivoire, 2003-2008

From: Incidence of serious morbidity in HIV-infected adults on antiretroviral therapy in a West African care centre, 2003-2008

  Overall WHO stage 3 or 4 ANRS grade 3 or 4
Parasitic diseases, n (%) 90 (32.4)     
  Confirmed malaria 87
  Parasitic enteritis 3
Mycobacterial diseases, n (%) 33 (11.9)     
  Tuberculosis 33 33
Bacterial diseases, n (%) 14 (5)     
  Septicemia 5 5
  Pneumonia 5 5
  Bacterial enteritis 2
  Pyelonephritis 2 2
Fungal diseases, n (%) 4 (1.4)     
  Esophageal candidiasis 1 1
  Oral candidiasis 3 3
Hematologic diseases, n (%) 39 (14)     
  Anemia 19 19
  Neutropenia 18 18
  Thrombopenia 2 2
Others , n (%) 50 (18)     
  Unexplained acute fever 14
  Unexplained acute diarrhea 7
  Unexplained prolonged fever 6 6
  Hyperlactatemia 5 5
  Unexplained pulmonary disease 3
  Elevated liver enzymes 2 2
  Toxiderma 2 2
  Acute delusional psychosis 1 1
  Herpes Zoster 1  
  Hypertension 1  
  Miscellaneous 8  
Death, n (%) 47 (16.9)
Total 278 (100) 61 (21.9) 49 (17.6)
  1. WHO, World Health Organization; ANRS, Agence Nationale de Recherche sur le SIDA et les Hépatites Virales.
  2. Septicemia: consistent clinical picture and clinically significant pathogen isolated from blood culture
  3. Pneumonia: Pulmonary symptoms, fever, chest radiographic evidence of alveolar pulmonary disease and : (i) successful response to antibiotherapy with no activity against Pneumocystis carinii; or (ii) clinically significant bacterial pathogen isolated from blood culture.
  4. Parasitic enteritis: diarrhea and clinically significant parasitic pathogen on stool examination.
  5. Bacterial enteritis: diarrhea and clinically significant bacterial pathogen isolated from stool culture.
  6. †: non-classifying events with ≥ one day at hospital, or leading to death.
  7. Unexplained acute fever: Fever > 37.5°C of unexplained origin for < 30 days.
  8. Unexplained prolonged fever: Fever > 37.5 of unexplained origin for ≥ 30 days, intermittent or constant.
  9. Unexplained pulmonary disease: pulmonary fibrosis, n = 1; mediastinal mass, n = 1.
  10. Zoster: patient with zoster of the ear canal, fever and meningeal syndrome. Negative blood films for malaria, negative blood culture and negative cerebrospinal fluid culture.