Characteristic | Patients with serological failure (n = 51) | Patients with serological cure (n = 509) | Odds ratio (95% CI) |
---|---|---|---|
Age, years | |||
<40 | 24 (8.8) | 250 (91.2) | 0.89 (.46-1.79) |
≥40 | 27 (9.4) | 259 (90.6) | 1 |
Race | |||
Hispanic | 22 (8.8) | 227 (91.2) | 1 |
White | 17 (7.9) | 197 (92.1) | 0.89 (.46-1.73) |
Black | 11 (17.7) | 51 (82.3) | 2.23 (1.02-4.88) |
Other/Unknown | 1 (2.9) | 34 (97.1) | 0.30 (.04-2.33) |
Methamphetamine use | 19 (9.9) | 172 (90.1) | 1.16 (.64-2.11) |
Hepatitis B or C | 11 (9.6) | 104 (90.4) | 1.07 (.53-.16) |
Syphilis history | 40 (13.8) | 249 (86.2) | 3.80 (1.91-7.56) |
Other | |||
STDa | 39 (9.3) | 380 (90.7) | 1.10 (.56- 2.17) |
RPR titer | |||
<1:32 | 23 (17.0) | 112 (83.0) | 2.91 (1.61-5.25) |
≥1:32 | 28 (6.6) | 397 (93.4) | 1 |
ART | 44 (9.1) | 442 (90.9) | 0.95 (.41- 2.20) |
CD4 T-cell count | |||
<350 cells/mL | 23 (16.0) | 121 (84.0) | 2.63 (1.46-4.74) |
≥350 cells/mL | 28 (6.7) | 388 (93.3) | 1 |
HIV RNA | |||
Undetectableb | 33 (8.2) | 369 (91.8) | 1 |
Detectable | 18 (11.4) | 140 (88.6) | 1.44 (.78-2.64) |
Early syphilis stage | |||
Primary | 9 (11.7) | 68 (88.3) | 1 |
Secondary | 10 (6.8) | 136 (93.2) | 0.56 (.22-1.43) |
Early latent | 32 (9.5) | 305 (90.5) | 0.79 (.36-1.74) |
Treatment regimen | |||
3 doses of benzathine penicillin | 43 (9.9) | 391 (90.1) | 1 |
1 dose of benzathine penicillin | 2 (4.3) | 45 (95.7) | 0.40 (.10-1.73) |
Doxycycline | 6 (7.7) | 72 (92.3) | 0.76 (.31-1.85) |
Azithromycin | 0 (0) | 1 (100) | NA |