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Table 2 Clinical characteristics and predictors of serological failure among 560 HIV-infected patients with early syphilis

From: Predictors of serological failure after treatment in HIV-infected patients with early syphilis in the emerging Era of universal antiretroviral therapy use

Characteristic Patients with serological failure (n = 51) Patients with serological cure (n = 509) Odds ratio (95% CI)
Age, years    
 <40 24 (8.8) 250 (91.2) 0.89 (.46-1.79)
 ≥40 27 (9.4) 259 (90.6) 1
Race    
 Hispanic 22 (8.8) 227 (91.2) 1
 White 17 (7.9) 197 (92.1) 0.89 (.46-1.73)
 Black 11 (17.7) 51 (82.3) 2.23 (1.02-4.88)
 Other/Unknown 1 (2.9) 34 (97.1) 0.30 (.04-2.33)
Methamphetamine use 19 (9.9) 172 (90.1) 1.16 (.64-2.11)
Hepatitis B or C 11 (9.6) 104 (90.4) 1.07 (.53-.16)
Syphilis history 40 (13.8) 249 (86.2) 3.80 (1.91-7.56)
Other    
STDa 39 (9.3) 380 (90.7) 1.10 (.56- 2.17)
RPR titer    
 <1:32 23 (17.0) 112 (83.0) 2.91 (1.61-5.25)
 ≥1:32 28 (6.6) 397 (93.4) 1
ART 44 (9.1) 442 (90.9) 0.95 (.41- 2.20)
CD4 T-cell count    
 <350 cells/mL 23 (16.0) 121 (84.0) 2.63 (1.46-4.74)
 ≥350 cells/mL 28 (6.7) 388 (93.3) 1
HIV RNA    
 Undetectableb 33 (8.2) 369 (91.8) 1
 Detectable 18 (11.4) 140 (88.6) 1.44 (.78-2.64)
Early syphilis stage    
 Primary 9 (11.7) 68 (88.3) 1
 Secondary 10 (6.8) 136 (93.2) 0.56 (.22-1.43)
 Early latent 32 (9.5) 305 (90.5) 0.79 (.36-1.74)
Treatment regimen    
 3 doses of benzathine penicillin 43 (9.9) 391 (90.1) 1
 1 dose of benzathine penicillin 2 (4.3) 45 (95.7) 0.40 (.10-1.73)
 Doxycycline 6 (7.7) 72 (92.3) 0.76 (.31-1.85)
 Azithromycin 0 (0) 1 (100) NA
  1. Data are no. (%) patients. OR, Odds Ratio; CI, confidence interval; RPR, rapid plasma regain test; STD, sexually transmitted disease; HIV, human immunodeficiency virus; DM, diabetes mellitus; ART, antiretroviral therapy.
  2. aOther STD include documented Neisseria gonorrhoeae, Chlamydia trachomatis, herpes, and genital warts.
  3. bDefined as <400 copies/mL.