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Table 3 Hazard ratios (HR) of mortality in 1024 patients on ART

From: Survival on antiretroviral treatment among adult HIV-infected patients in Nepal: a retrospective cohort study in far-western Region, 2006–2011

Determinants Univariate analysis Multivariate analysisf
  HR (95% CI) P value HR (95% CI) P value
Place of ART a     
Kailali Districb (ref.) 1.00    
Kanchanpur Districtb 2.03 (1.10 – 3.73) 0.023   
Doti Districtc 1.93 (1.24 – 3.00) 0.004   
Achham Districtc 1.71 (1.05 – 2.78) 0.031   
Sex     
Female (ref.) 1.00   1.00  
Male 5.40 (3.37 – 8.65) <0.001 4.55 (2.43 – 8.51) <0.001
Age groups (years)     
15- 32 years (ref.) 1.00    
33- 40 years 1.66 (1.04 – 2.64) 0.033   
>40 years 1.93 (1.19 – 3.14) 0.008   
Education     
Illiterate (ref.) 1.00    
Literate 1.45 (0.96 – 2.17) 0.075   
Performance scale     
Normal (ref.) 1.00   1.00  
Bedridden <50% 4.54 (2.99 – 6.88) <0.001 2.05 (1.19 – 3.52) 0.010
Bedridden >50% 5.53 (3.45 – 8.87) <0.001 3.41 (1.67 – 6.98) 0.001
Bodyweight (Kg)d 1.02(1.01 – 1.05)g 0.048 1.04(1.01 – 1.07)g 0.010
WHO clinical stage     
Stage I or II (ref.) 1.00   1.00  
Stage III 4.39 (2.25- 8.55) <0.001 2.96 (1.31- 6.69) 0.009
Stage IV 8.85 (4.43-17.66) <0.001 3.28 (1.30- 8.29) 0.012
CD4 count (cells/mm 3)d 0.99 (0.98- 0.99) <0.001   
Drug toxicity/side effects     
No (ref.) 1.00    
Yes 1.45 (0.96- 2.19) 0.078   
Active TB during treatment     
No (ref.) 1.00    
Yes 1.73 (1.15- 2.61) 0.009   
ART regimen e     
d4T/3TC/NVP (ref.) 1.00    
d4T/3TC/EFV 0.90 (0.39- 2.07) 0.803   
ZDV/3TC/NVP 0.49 (0.31- 0.77) 0.002   
ZDV/3TC/EFV 0.97 (0.54- 1.73) 0.907   
ART regimen change     
No (ref.) 1.00    
Yes 1.37 (0.94- 2.00) 0.10   
  1. aKailali District (Seti Zonal Hospital and Tikapur Hospital), Kanchanpur District (Kanchanpur Zonal Hospital), Doti District (Doti District Hospital), and Achham District (Achham District Hospital). bplain/terai district, chill district . dContinuous variables. eTDF/3TC/EFV regimen was not included. fCox proportional hazards model adjusted for all variables in the table. gHR for 1 kg decrease in bodyweight.
  2. ref.: reference group.