Table 2 Treatment outcomes of ASAQ, AL and DHAPQ at day 28
Outcome | Uncorrected | PCR-Corrected | ||||||
|---|---|---|---|---|---|---|---|---|
DHAPQ (N = 176) | AL (N = 178) | ASAQ (N = 180) | p-value | DHAPQ (N = 176) | AL (N = 178) | ASAQ (N = 180) | p-value | |
% (95% CI) | % (95% CI) | % (95% CI) | % (95% CI) | % (95% CI) | % (95% CI) | |||
Intention to treat analysis | ||||||||
Early treatment failure | 00 | 00 | 00 | 00 | 00 | 00 | ||
NA | 6/176 (3.41%) | 2/178 (1.12%) | 4/180 (2.22%) | 6/176 (3.41%) | 2/178 (1.12%) | 4/180 (2.22%) | ||
Late parasitological failure | 1/176 (0.57%) | 1/178 (0.56%) | 2/180 (1.1%) | 00 | 00 | 1/180 (0.56%) | ||
ACPR | 169/176 (96.02%) | 175/178 (98.31%) | 174/180 (96.67%) | 0.43 | 170/176 (96.59%) | 176/178 (98.88%) | 175/180 (97.22%) | 0.35 |
[89.3-99.9] | [87.3-99.9] | [88.8-99.9] | [88.7-99.9] | [86.8-99.9] | [88.4-99.9] | |||
Per protocol analysis | DHAPQ (N = 162) | AL (N = 172) | ASAQ (N = 169) | DHAPQ (N = 162) | AL (N = 172) | ASAQ (N = 169) | ||
% (95% CI) | % (95% CI) | % (95% CI) | % (95% CI) | % (95% CI) | % (95% CI) | |||
Early treatment failure | 00 | 00 | 00 | 00 | 00 | 00 | ||
Late parasitological failure | 1/162 (0.62%) | 1/172 (0.58%) | 1/169 (0.59%) | 00 | 00 | 1/169 (0.59%) | ||
ACPR | 161/162 (99.38%) | 171/172 (99.42%) | 168/169 (99.41) | 0.99 | 162/162 (100%) | 172/172 (100%) | 168/169 (99.41) | 0.37 |
[85.7-99.9] | [86.1-99.9] | [86–99.9] | [85.2-99.9] | [85.6-99.9] | [86–99.9] | |||